ST6GAL1 and NAT8

Data Source:
BioGRID (affinity chromatography technology)

		ST6GAL1	NAT8
Description		ST6 beta-galactoside alpha-2,6-sialyltransferase 1	N-acetyltransferase 8 (putative)
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Integral Component Of Membrane Golgi Cisterna Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Beta-galactoside Alpha-2,6-sialyltransferase Activity Protein Binding Sialyltransferase Activity Protein Homodimerization Activity	Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding N-acetyltransferase Activity Cysteine-S-conjugate N-acetyltransferase Activity
	Biological Process	N-acetylneuraminate Metabolic Process Humoral Immune Response O-glycan Processing Protein N-linked Glycosylation Via Asparagine Sialylation	Glutathione Metabolic Process Positive Regulation Of Gene Expression Peptidyl-lysine N6-acetylation Response To Drug Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Amyloid-beta Metabolic Process
Pathways		Sialic acid metabolism Maturation of protein 3a Maturation of spike protein Maturation of protein 3a N-Glycan antennae elongation Termination of O-glycan biosynthesis	Amyloid fiber formation
Drugs
Diseases
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Albumin-globulin ratio ( 29403010) Blood protein levels ( 29875488) Drug-induced liver injury (flucloxacillin) ( 19483685) Eosinophil percentage of white cells ( 32888494) Esophageal cancer (squamous cell) ( 22960999) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) IgA nephropathy ( 26028593) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG monosialylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Immature fraction of reticulocytes ( 32888494) N-glycan levels ( 31163085) Non-albumin protein levels ( 29403010) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132) Thyroglobulin plasma levels ( 30929638) Type 2 diabetes ( 30054458 21874001 30297969 32499647 30718926)	Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Chronic kidney disease ( 20383146) Creatinine levels ( 20383145) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 23535967) Glomerular filtration rate (creatinine) ( 28452372) Hemoglobin levels ( 32327693) Metabolic traits ( 21886157) Metabolite levels ( 21931564) Metabolite levels (X-11787) ( 23934736) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 24625756 23093944) Urinary metabolite levels in chronic kidney disease ( 29545352 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolites ( 26352407)
Interacting Genes		1 interacting genes: CD22	29 interacting genes: ARL13B ATP6V0E1 BIK CD79A CERS4 CREB3L1 EBP FAM209A FFAR2 GOLT1A GPR152 HSD17B13 JPH1 LEPROTL1 LMNA MFSD14B MTIF3 REEP2 SAR1A SLC10A6 SMAD4 TGFBR1 TLCD4 TMEM143 TMEM14B TMEM31 TMX2 TSPAN31 YIPF4
Entrez ID		6480	9027
HPRD ID		00184	08413
Ensembl ID		ENSG00000073849	ENSG00000144035
Uniprot IDs		P15907	Q9UHE5
PDB IDs		4JS1 4JS2 6QVS 6QVT
Enriched GO Terms of Interacting Partners?
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