GAREM1 and GRAP2

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid)

		GAREM1	GRAP2
Description		GRB2 associated regulator of MAPK1 subtype 1	GRB2 related adaptor protein 2
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GO Annotations	Cellular Component	Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane
	Molecular Function	Protein Binding Proline-rich Region Binding	Protein Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Division Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus	Ras Protein Signal Transduction Cell-cell Signaling T Cell Costimulation Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway
Pathways			Signaling by SCF-KIT Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 co-stimulation FLT3 Signaling
Drugs
Diseases
GWAS		Breast cancer ( 29059683) Left ventricular internal dimension in diastole ( 29403010) Left ventricular internal dimension in systole ( 29403010)	Body mass index ( 26426971) Systemic lupus erythematosus ( 28714469)
Interacting Genes		5 interacting genes: CRK CRKL GRAP2 GRB2 NCK2	79 interacting genes: AR BAG4 BEND5 BLNK CBL CBLB CBY2 CCHCR1 CCNDBP1 CD28 COG6 CSF1R DNM2 DVL2 EGFR ERBB2 ERBB3 ERBB4 ETV5 FASLG GAB1 GAB2 GAB3 GAREM1 GATA1 GFAP GOLGA2 GRB2 HNRNPK IHO1 IKZF3 KHDRBS1 KHDRBS2 KIT KPRP KRT13 KRTAP1-3 KRTAP4-11 KRTAP4-12 LAT LATS2 LAX1 LCP2 LNX1 LNX2 MAGED1 MAP4K1 MKRN3 MOS MTUS2 PBLD PNMA1 PRKAA2 PRPH2 PRR35 RACK1 RAVER1 RBPMS RIN3 RINT1 SH2D4A SHB SHC1 SOS2 SPRY2 SSX2IP STAMBP TFIP11 TLE5 TRAF1 TSNAXIP1 USP8 WWP2 YWHAE ZBTB7B ZNF250 ZNF319 ZNF526 ZSCAN21
Entrez ID		64762	9402
HPRD ID		12685	05156
Ensembl ID		ENSG00000141441	ENSG00000100351
Uniprot IDs		Q9H706	B7Z8E3 O75791 Q6FI14
PDB IDs		2DKZ	5GJH
Enriched GO Terms of Interacting Partners?
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