TNS3 and BCAR1

Data Source:
BioGRID (pull down)

		TNS3	BCAR1
Description		tensin 3	BCAR1 scaffold protein, Cas family member
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Focal Adhesion	Ruffle Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium Axon
	Molecular Function	Protein Binding	Protein Binding SH3 Domain Binding Protein Kinase Binding
	Biological Process		Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis Endothelin Receptor Signaling Pathway Actin Filament Reorganization
Pathways		MET interacts with TNS proteins	Downstream signal transduction p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases
GWAS		Alcohol dependence symptom count ( 29460428) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Basal cell carcinoma ( 31174203 27539887) Birth weight ( 31043758) Colorectal cancer (diet interaction) ( 24743840) Diastolic blood pressure ( 27841878) Dimensional psychopathology (Positive) ( 29496196) Electroencephalogram traits ( 25387704) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Granulocyte count ( 27863252) Height ( 31562340) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Insulin-like growth factors ( 21216879) Iris color (a* coordinate) ( 30895295) Keratinocyte cancer (MTAG) ( 31174203) Male-pattern baldness ( 27182965) Molybdenum levels ( 26025379) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Pancreatic cancer ( 29422604) Prostate cancer ( 25217961) Pulse pressure ( 30224653 27841878 29403010) QRS duration ( 27659466) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 27841878) Thyroid stimulating hormone levels ( 32769997) White blood cell count ( 32888494)	Advanced age-related macular degeneration ( 26691988) Alcoholic chronic pancreatitis ( 28754779) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Coronary artery disease ( 33020668) Crohn's disease (time to surgery) ( 23665963) Intracranial aneurysm ( 33199917) Offspring birth weight ( 31043758) Pancreatic cancer ( 29422604 25086665) Type 1 diabetes ( 25751624) Type 2 diabetes ( 22885922 29358691 30297969)
Interacting Genes		11 interacting genes: BCAR1 EGFR EPHA4 ERBB2 ERBB3 ERBB4 GAB1 KIT MET PTK2 SRPK2	65 interacting genes: ABL1 AJUBA ANKS1A ARHGAP32 BMX CASP3 CD2AP COPB1 CRK CRKL CSPG4 DOCK1 DOK7 E2F2 EFS ESR1 FAM102A FAM90A1 FES FXYD6 FYB1 FYN GLIS2 GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NCK2 NEDD9 NPHP1 PIK3R1 PKD1 PLPP3 PPP1R15A PRAM1 PTEN PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TNS3 TRIP6 TUBA4A UHRF2 USP2 VCL VPS11 YES1 YWHAZ
Entrez ID		64759	9564
HPRD ID		08438	04248
Ensembl ID		ENSG00000136205	ENSG00000050820
Uniprot IDs		Q68CZ2	B3KWE2 P56945
PDB IDs			1WYX 3T6G 5O2M 5O2P 5O2Q
Enriched GO Terms of Interacting Partners?
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