SHMT2 and ABRAXAS2

Data Source:
BioGRID (pull down)

		SHMT2	ABRAXAS2
Description		serine hydroxymethyltransferase 2	abraxas 2, BRISC complex subunit
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol Microtubule Cytoskeleton Mitochondrial Nucleoid Extracellular Exosome BRISC Complex	Nucleus Cytoplasm Centrosome Cytosol Midbody Spindle Pole Centrosome Microtubule Minus-end BRISC Complex
	Molecular Function	Translation Repressor Activity, MRNA Regulatory Element Binding Chromatin Binding Glycine Hydroxymethyltransferase Activity Protein Binding Zinc Ion Binding L-allo-threonine Aldolase Activity Pyridoxal Phosphate Binding Protein Homodimerization Activity MRNA 5'-UTR Binding Cobalt Ion Binding Serine Binding	Protein Binding Microtubule Binding Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Regulation Of Oxidative Phosphorylation Glycine Metabolic Process L-serine Metabolic Process L-serine Biosynthetic Process L-serine Catabolic Process One-carbon Metabolic Process Positive Regulation Of Cell Population Proliferation Purine Nucleobase Biosynthetic Process Negative Regulation Of Translation Glycine Biosynthetic Process From Serine Response To Type I Interferon Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Protein Tetramerization Protein Homotetramerization Regulation Of Mitochondrial Translation Protein K63-linked Deubiquitination Regulation Of Aerobic Respiration	Mitotic Cell Cycle Response To Ischemia Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Protein Deubiquitination Cell Division Protein K63-linked Deubiquitination Mitotic Spindle Assembly
Pathways		Metabolism of folate and pterines	Metalloprotease DUBs
Drugs		Pyridoxal phosphate Tetrahydrofolic acid Glycine Artenimol
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Schizophrenia ( 25056061 29483656)	Bone mineral content ( 31790847)
Interacting Genes		18 interacting genes: ABRAXAS2 APP ARL6IP1 BABAM1 BABAM2 BRCC3 CAB39 CLEC2D CMTM5 CREB3 CSNK2B DUX4 ESR1 FBXO7 KASH5 MAL2 NDRG1 PPARD	7 interacting genes: DCUN1D1 NUMA1 SHMT2 SMURF2 THAP5 UBC USP7
Entrez ID		6472	23172
HPRD ID		00717	13783
Ensembl ID		ENSG00000182199	ENSG00000165660
Uniprot IDs		A0A024RB99 B4DJQ3 B4DLV4 P34897 Q5BJF5 Q5HYG8 V9HW06	Q15018
PDB IDs		4PVF 5V7I 5X3V 6DK3 6H3C 6QVG 6QVL 6R8F	6H3C 6R8F
Enriched GO Terms of Interacting Partners?
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