SHMT1 and SULT1A3

Data Source:
BioGRID (two hybrid)

		SHMT1	SULT1A3
Description		serine hydroxymethyltransferase 1	sulfotransferase family 1A member 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Translation Repressor Activity, MRNA Regulatory Element Binding Glycine Hydroxymethyltransferase Activity Protein Binding Zinc Ion Binding L-allo-threonine Aldolase Activity Pyridoxal Phosphate Binding Small Molecule Binding Identical Protein Binding Protein Homodimerization Activity MRNA 5'-UTR Binding Cobalt Ion Binding Serine Binding	Aryl Sulfotransferase Activity Protein Binding Sulfotransferase Activity Sulfate Binding Amine Sulfotransferase Activity
	Biological Process	Glycine Metabolic Process L-serine Metabolic Process L-serine Catabolic Process One-carbon Metabolic Process Purine Nucleobase Biosynthetic Process Negative Regulation Of Translation Glycine Biosynthetic Process From Serine Tetrahydrofolate Interconversion Carnitine Biosynthetic Process Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Protein Homotetramerization Cellular Response To Tetrahydrofolate Cellular Response To Leukemia Inhibitory Factor	Ethanol Catabolic Process Xenobiotic Metabolic Process Dopamine Receptor Signaling Pathway Steroid Metabolic Process Flavonoid Metabolic Process IRE1-mediated Unfolded Protein Response Dopamine Catabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation ERK1 And ERK2 Cascade Calcineurin-mediated Signaling NMDA Selective Glutamate Receptor Signaling Pathway Negative Regulation Of Neuron Death Cellular Response To Dopamine
Pathways		Metabolism of folate and pterines Carnitine synthesis	Cytosolic sulfonation of small molecules XBP1(S) activates chaperone genes Cytosolic sulfonation of small molecules
Drugs		Pyridoxal phosphate Tetrahydrofolic acid Glycine Mimosine Triglu-5-formyl-tetrahydrofolate 5-hydroxymethyl-5,6-dihydrofolic acid N-Pyridoxyl-Glycine-5-Monophosphate
Diseases
GWAS		Blood protein levels ( 30072576) Change in neurofilament light levels ( 31295725) Multiple sclerosis ( 27386562)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: CSNK2B DDX6 DEDD DLEU1 FBXO7 GORASP2 MAPK9 MDFI PIM1 PRSS23 SULT1A3	6 interacting genes: APP KHDRBS2 NIF3L1 SHMT1 SMN1 TK1
Entrez ID		6470	6818
HPRD ID		01643	07199
Ensembl ID		ENSG00000176974	ENSG00000261052
Uniprot IDs		P34896	P0DMM9 P0DMN0 Q1ET61
PDB IDs		1BJ4 6FL5	1CJM 2A3R
Enriched GO Terms of Interacting Partners?
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