SGCD and ADA

Data Source:
BioGRID (two hybrid)

		SGCD	ADA
Description		sarcoglycan delta	adenosine deaminase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Sarcoglycan Complex Integral Component Of Membrane Sarcolemma	Extracellular Space Lysosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Junction Dendrite Cytoplasm Neuronal Cell Body Cytoplasmic Vesicle Lumen
	Molecular Function		Purine Nucleoside Binding Adenosine Deaminase Activity Protein Binding Zinc Ion Binding
	Biological Process	Muscle Organ Development Cardiac Muscle Tissue Development Heart Contraction	Response To Hypoxia Histamine Secretion Trophectodermal Cell Differentiation Liver Development Placenta Development Germinal Center B Cell Differentiation Positive Regulation Of Germinal Center Formation Negative Regulation Of Leukocyte Migration Negative Regulation Of Mature B Cell Apoptotic Process Adenosine Catabolic Process Deoxyadenosine Catabolic Process Cell Adhesion Aging Purine Ribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Heart Rate Positive Regulation Of B Cell Proliferation Purine Nucleotide Salvage Positive Regulation Of T Cell Differentiation In Thymus Response To Vitamin E Regulation Of Cell-cell Adhesion Mediated By Integrin T Cell Activation Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Response To Drug Response To Hydrogen Peroxide Purine-containing Compound Salvage Hypoxanthine Salvage Response To Morphine Positive Regulation Of Smooth Muscle Contraction DAMP Catabolic Process DATP Catabolic Process Inosine Biosynthetic Process Xanthine Biosynthetic Process Positive Regulation Of Alpha-beta T Cell Differentiation Lung Alveolus Development Peyer's Patch Development Embryonic Digestive Tract Development Negative Regulation Of Inflammatory Response Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Negative Regulation Of Thymocyte Apoptotic Process Negative Regulation Of Mucus Secretion
Pathways			Purine salvage
Drugs			Pentostatin Dipyridamole FR221647 7,8-dihydroinosine FR117016 FR236913 6-hydroxy-1,6-dihydro purine nucleoside FR-234938 FR239087 FR230513 1-Deaza-Adenosine Nebularine (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
Diseases		Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F Limb-girdle muscular dystrophy (LGMD) Dilated cardiomyopathy (DCM)	T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Anthropometric traits ( 19260139) Daytime sleep phenotypes ( 27126917) Egg allergy ( 25710614) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Evening vs. morning chronotype (sMEQ score) ( 32579418) Glycemic traits (pleiotropy) ( 31021400) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HIV-1 viral setpoint ( 26039976) Multiple sclerosis (age of onset) ( 19010793) Obesity-related traits ( 23251661) Pulse pressure ( 30578418) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Resting-state electroencephalogram vigilance ( 29703947) Superior temporal sulcus banks volume ( 31530798) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)	Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908 23128233)
Interacting Genes		6 interacting genes: ADA FLNC SERPINA3 SGCA SGCB SGCG	11 interacting genes: ADORA1 ADORA2A ADORA2B DPP4 DRD1 GRB2 NR3C1 PIAS2 SGCD TERF2IP TINF2
Entrez ID		6444	100
HPRD ID		03246	00038
Ensembl ID		ENSG00000170624	ENSG00000196839
Uniprot IDs		Q92629	A0A0S2Z381 F5GWI4 P00813
PDB IDs			1M7M 3IAR
Enriched GO Terms of Interacting Partners?
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