HIF3A and EGLN2

Data Source:
HPRD (in vitro)

		HIF3A	EGLN2
Description		hypoxia inducible factor 3 subunit alpha	egl-9 family hypoxia inducible factor 2
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Mitochondrion Cytosol Plasma Membrane Nuclear Speck	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Dimerization Activity	Protein Binding Ferrous Iron Binding 2-oxoglutarate-dependent Dioxygenase Activity Oxygen Sensor Activity L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity
	Biological Process	Angiogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Protein Ubiquitination Post-translational Protein Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia	Regulation Of Cell Growth Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Intracellular Estrogen Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Cell Redox Homeostasis Positive Regulation Of Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia
Pathways		Regulation of gene expression by Hypoxia-inducible Factor Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Transcriptional regulation of pluripotent stem cells Neddylation	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs			Ascorbic acid Roxadustat
Diseases
GWAS		Free cholesterol levels in medium VLDL ( 29084231) Medium VLDL particle concentration ( 29084231) Phospholipid levels in large VLDL ( 29084231) Phospholipid levels in medium VLDL ( 29084231) Phospholipid levels in small VLDL ( 29084231) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Small VLDL particle concentration ( 29084231) Total cholesterol levels in medium VLDL ( 29084231) Total triglycerides levels ( 29084231) Triglyceride levels in large VLDL ( 29084231) Triglyceride levels in medium VLDL ( 29084231) Triglyceride levels in small VLDL ( 29084231) Very large VLDL particle concentration ( 29084231) Weight ( 28552196)	Carotid intima media thickness (mean) ( 31801372) Chronic obstructive pulmonary disease ( 22080838) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Nicotine metabolite ratio in current smokers ( 28921760) Parental longevity (father's attained age) ( 29227965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Red blood cell count ( 32888494) Smoking behavior ( 20418890) Smoking behaviour (cigarettes smoked per day) ( 30617275)
Interacting Genes		7 interacting genes: ARNT EGLN1 EGLN2 EGLN3 HIF1A HSP90AA1 VHL	11 interacting genes: A2M CDK2 EPAS1 HIF1A HIF3A MFHAS1 MOB4 PRKCA SPOP SRPK2 TENT5A
Entrez ID		64344	112398
HPRD ID		17104	06970
Ensembl ID		ENSG00000124440	ENSG00000269858
Uniprot IDs		B2RBI6 H0YDZ5 M0R104 Q9Y2N7	A0A024R0R2 Q96KS0
PDB IDs		4WN5	5V1B
Enriched GO Terms of Interacting Partners?
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