HS1BP3 and HCLS1

Data Source:
HPRD (in vivo)

		HS1BP3	HCLS1
Description		HCLS1 binding protein 3	hematopoietic cell-specific Lyn substrate 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum	Nucleus Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Actin Filament Plasma Membrane Site Of Polarized Growth Cortical Actin Cytoskeleton
	Molecular Function	Protein Binding Phosphatidylinositol Binding	RNA Polymerase II Transcription Factor Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Actin Filament Binding
	Biological Process	Regulation Of Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Population Proliferation Response To Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Filament Polymerization Erythrocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) Low density lipoprotein cholesterol levels ( 29403010) Total cholesterol levels ( 29403010) Waist-hip ratio ( 28552196)
Interacting Genes		2 interacting genes: HCLS1 ZDHHC17	24 interacting genes: ACTA1 ACTR2 ACTR3 BLZF1 CASP3 CD79A CSNK2A1 FGR GRB2 HAX1 HS1BP3 IKBKG LYN LZTR1 MAP4K1 QKI SH2D4A SH3BP2 SSBP3 SYK TERF1 TRIM29 WAS ZBTB25
Entrez ID		64342	3059
HPRD ID		13357	03199
Ensembl ID		ENSG00000118960	ENSG00000180353
Uniprot IDs		Q53T59 Q9H7U7	P14317
PDB IDs
Enriched GO Terms of Interacting Partners?
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