SETMAR and XRN2

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SETMAR	XRN2
Description		SET domain and mariner transposase fusion gene	5'-3' exoribonuclease 2
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleolus Site Of Double-strand Break	Nucleus Nucleoplasm Nucleolus Membrane Aggresome
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Endonuclease Activity Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Protein Homodimerization Activity DNA Topoisomerase Binding Histone Methyltransferase Activity (H3-K36 Specific)	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Identical Protein Binding Metal Ion Binding
	Biological Process	DNA Double-strand Break Processing DNA Catabolic Process, Endonucleolytic Double-strand Break Repair Via Nonhomologous End Joining Cell Population Proliferation Histone H3-K36 Methylation DNA Integration Replication Fork Processing Mitotic DNA Integrity Checkpoint Histone H3-K4 Methylation Negative Regulation Of Cell Cycle Arrest Nucleic Acid Phosphodiester Bond Hydrolysis Histone H3-K36 Dimethylation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Chromosome Organization	DNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Fractures (paediatric) ( 32742401) Midgestational circulating levels of PCBs ( 28235828) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Autism spectrum disorder ( 30804558) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		1 interacting genes: H3-5	28 interacting genes: ALDH1B1 ATRN COMT CRY2 CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MOCS3 MRPL4 MRPS10 PLEKHF2 PRAME PSMA3 TARDBP TIPARP TOLLIP TTC23 UPF2
Entrez ID		6419	22803
HPRD ID		10225	10309
Ensembl ID		ENSG00000170364	ENSG00000088930
Uniprot IDs		B4DND2 Q53H47 Q96H41	B4DZC3 Q9H0D6
PDB IDs		3BO5 3F2K 3K9J 3K9K
Enriched GO Terms of Interacting Partners?
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