CLSPN and USP29

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		CLSPN	USP29
Description		claspin	ubiquitin specific peptidase 29
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus	Cellular_component Nucleus Cytosol
	Molecular Function	DNA Secondary Structure Binding Protein Binding Anaphase-promoting Complex Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity
	Biological Process	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Mitotic G2 DNA Damage Checkpoint Protein Deubiquitination Peptidyl-serine Phosphorylation Activation Of Protein Kinase Activity Mitotic DNA Replication Checkpoint	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation
Pathways		Apoptotic cleavage of cellular proteins Activation of ATR in response to replication stress Ub-specific processing proteases Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Urate levels in lean individuals ( 25811787)
Interacting Genes		11 interacting genes: ATR BRCA1 CASP7 CDC7 CHEK1 FZR1 RAD9A USP20 USP28 USP29 USP7	2 interacting genes: CLSPN HRAS
Entrez ID		63967	57663
HPRD ID		09257	07163
Ensembl ID		ENSG00000092853	ENSG00000131864
Uniprot IDs		Q9HAW4	Q9HBJ7
PDB IDs
Enriched GO Terms of Interacting Partners?
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