PCIF1 and PDX1

Data Source:
HPRD (in vivo, in vitro)

		PCIF1	PDX1
Description		phosphorylated CTD interacting factor 1	pancreatic and duodenal homeobox 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Microtubule Cytoskeleton Intercellular Bridge	Chromatin Nucleus Nucleoplasm Cytosol Nuclear Speck
	Molecular Function	MRNA (2'-O-methyladenosine-N6-)-methyltransferase Activity RNA Polymerase II C-terminal Domain Binding S-adenosyl-L-methionine Binding RNA Polymerase II C-terminal Domain Phosphoserine Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Factor Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of Translation Negative Regulation Of Phosphatase Activity Negative Regulation Of Translation Positive Regulation Of Translation MRNA Methylation	Negative Regulation Of Transcription By RNA Polymerase II Liver Development Type B Pancreatic Cell Differentiation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Smoothened Signaling Pathway Nitric Oxide Mediated Signal Transduction Central Nervous System Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Wounding Animal Organ Morphogenesis Response To Iron(II) Ion Response To Chlorate Animal Organ Senescence Positive Regulation Of Cell Death Morphogenesis Of Embryonic Epithelium Insulin Secretion Exocrine Pancreas Development Animal Organ Regeneration Response To Vitamin Response To Cytokine Response To Nicotine Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Drug Glucose Homeostasis Response To Leucine Response To Alkaloid Positive Regulation Of DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Stem Cell Differentiation Response To Glucocorticoid Detection Of Glucose Transdifferentiation Response To Fatty Acid Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways			Regulation of gene expression in beta cells Regulation of gene expression in early pancreatic precursor cells
Drugs
Diseases			Maturity onset diabetes of the young (MODY) Pancreatic agenesis Permanent neonatal diabetes mellitus (PNDM)
GWAS		Abdominal aortic aneurysm ( 27899403) Coronary artery disease ( 29212778) Gut microbiota (functional units) ( 27694959) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin levels ( 26366553) High density lipoprotein cholesterol levels ( 29403010) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 29403010 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Acute insulin response ( 28490609) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Birth weight ( 31043758) Blood sugar levels ( 29403010) Body mass index ( 26426971) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 28270201) Glycated hemoglobin levels ( 28898252) Pancreatic cancer ( 29422604 26098869 25086665) Peak insulin response ( 28490609)
Interacting Genes		3 interacting genes: APP PDX1 POLR2A	13 interacting genes: ATF3 CREB1 IAPP MAFA NEUROD1 PBX1 PCIF1 PRKDC SLC2A2 SPOP TCF3 XRCC5 XRCC6
Entrez ID		63935	3651
HPRD ID		12779	02843
Ensembl ID		ENSG00000100982	ENSG00000139515
Uniprot IDs		Q9H4Z3	P52945
PDB IDs		2JX8 6IRV 6IRW	6F8F
Enriched GO Terms of Interacting Partners?
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