SDHB and PIK3R5

Data Source:
BioGRID (two hybrid)

		SDHB	PIK3R5
Description		succinate dehydrogenase complex iron sulfur subunit B	phosphoinositide-3-kinase regulatory subunit 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex II, Succinate Dehydrogenase Complex (ubiquinone) Plasma Membrane Mitochondrial Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IB Membrane Centriolar Satellite
	Molecular Function	Protein Binding Succinate Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Metal Ion Binding Ubiquinone Binding 2 Iron, 2 Sulfur Cluster Binding 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	G-protein Beta/gamma-subunit Complex Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Tricarboxylic Acid Cycle Succinate Metabolic Process Aerobic Respiration Respiratory Electron Transport Chain	Phosphatidylinositol Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Platelet Activation Positive Regulation Of MAP Kinase Activity Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Protein Kinase B Signaling
Pathways		Respiratory electron transport Citric acid cycle (TCA cycle)	GPVI-mediated activation cascade Synthesis of PIPs at the plasma membrane G beta:gamma signalling through PI3Kgamma Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Ubiquinone Q1
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 20189936) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Atypical femoral fracture in phosphonate treatment ( 31006051) Autoimmune thyroid disease ( 32581359) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494)
Interacting Genes		6 interacting genes: ABCA1 CARTPT GEM PIK3R5 SPRY2 XRN1	4 interacting genes: APP PIK3CG SDHB SNX9
Entrez ID		6390	23533
HPRD ID		01707	11433
Ensembl ID		ENSG00000117118	ENSG00000141506
Uniprot IDs		P21912	J3KSW1 L7RT34 Q8WYR1
PDB IDs
Enriched GO Terms of Interacting Partners?
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