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CCL20 and PF4
Data Source:
BioGRID
(pull down)
CCL20
PF4
Description
C-C motif chemokine ligand 20
platelet factor 4
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Extracellular Region
Extracellular Space
Cytoplasm
Symbiont-containing Vacuole Membrane
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Molecular Function
Protein Binding
Chemokine Activity
CCR6 Chemokine Receptor Binding
CCR Chemokine Receptor Binding
Protein Binding
Chemokine Activity
Heparin Binding
CXCR Chemokine Receptor Binding
CXCR3 Chemokine Receptor Binding
Biological Process
Monocyte Chemotaxis
Chemotaxis
Inflammatory Response
Immune Response
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Cytokine-mediated Signaling Pathway
Neutrophil Chemotaxis
Calcium-mediated Signaling Using Intracellular Calcium Source
Defense Response To Bacterium
Positive Regulation Of GTPase Activity
Lymphocyte Chemotaxis
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
T Cell Migration
Thymocyte Migration
Positive Regulation Of T Cell Migration
Platelet Degranulation
Inflammatory Response
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Platelet Activation
Neutrophil Chemotaxis
Leukocyte Chemotaxis
Positive Regulation Of Tumor Necrosis Factor Production
Regulation Of Cell Population Proliferation
Defense Response To Protozoan
Negative Regulation Of MHC Class II Biosynthetic Process
Positive Regulation Of Macrophage Differentiation
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Killing By Host Of Symbiont Cells
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Chemokine-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Platelet degranulation
Common Pathway of Fibrin Clot Formation
Cell surface interactions at the vascular wall
Chemokine receptors bind chemokines
G alpha (i) signalling events
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Drotrecogin alfa
Heparin
Diseases
GWAS
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
31959851
30929738
32296059
)
Asthma (childhood onset) (
31036433
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Blood pressure (
17903302
)
Crohn's disease (
26192919
)
Eating disorders (purging via substances) (
23568457
)
Inflammatory bowel disease (
26192919
)
Primary biliary cholangitis (
26394269
)
Ulcerative colitis (
26192919
)
Inflammatory bowel disease (
23128233
)
Metabolite levels (
22916037
)
Serum metabolite levels (
31636271
)
Serum metabolite levels (CMS) (
31636271
)
Interacting Genes
11 interacting genes:
CCL5
CCR6
CXCL11
CXCL12
CXCL17
CXCL5
MTDH
PF4
TGFB3
VCAN
XCL2
28 interacting genes:
CCL11
CCL13
CCL2
CCL20
CCL21
CCL25
CCL26
CCL28
CCL5
CXCL10
CXCL11
CXCL12
CXCL14
CXCL17
CXCL2
CXCL6
CXCL8
CXCL9
CXCR3
FGF2
LDLR
PROC
SDC2
SRGN
THBD
VCAN
XCL1
XCL2
Entrez ID
6364
5196
HPRD ID
03571
01426
Ensembl ID
ENSG00000115009
ENSG00000163737
Uniprot IDs
P78556
P02776
PDB IDs
1M8A
2HCI
2JYO
5UR7
6WWZ
1DN3
1F9Q
1F9R
1F9S
1PFM
1PFN
1RHP
4R9W
4R9Y
4RAU
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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