CCL19 and PPM1E

Data Source:
HPRD (in vivo)

		CCL19	PPM1E
Description		C-C motif chemokine ligand 19	protein phosphatase, Mg2+/Mn2+ dependent 1E
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleus Nucleoplasm Nucleolus Mitochondrion Protein-containing Complex
	Molecular Function	Protein Binding Chemokine Activity CCR7 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Establishment Of T Cell Polarity Immunological Synapse Formation Dendritic Cell Chemotaxis Myeloid Dendritic Cell Chemotaxis Monocyte Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Cellular Calcium Ion Homeostasis Inflammatory Response Immune Response Cell Communication G Protein-coupled Receptor Signaling Pathway Activation Of JUN Kinase Activity Response To Virus Positive Regulation Of Glycoprotein Biosynthetic Process Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis T Cell Costimulation Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Prostaglandin E Positive Regulation Of T Cell Proliferation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Endocytosis Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Lymphocyte Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Kinase B Signaling Regulation Of Cell Projection Assembly Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Response To Nitric Oxide Positive Regulation Of Neutrophil Chemotaxis Mature Conventional Dendritic Cell Differentiation Cellular Response To Virus Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Cell Motility Positive Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Apoptotic Process	Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Cellular Response To Drug Peptidyl-threonine Dephosphorylation Positive Regulation Of Stress Fiber Assembly
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Negative regulation of NMDA receptor-mediated neuronal transmission
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Rheumatoid arthritis ( 30423114 24390342)	Circulating myeloperoxidase levels (plasma) ( 23620142) Cognitive function ( 25644384) Cognitive test performance ( 17903297) Intelligence (MTAG) ( 29326435) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Systolic blood pressure ( 30224653 30578418) Testicular germ cell tumor ( 23666239)
Interacting Genes		8 interacting genes: ACKR2 ACKR4 CCL22 CCR10 CCR7 CXCL13 MEOX2 PF4V1	5 interacting genes: ARHGEF7 DISC1 GAPDH PRKAA1 TNIK
Entrez ID		6363	22843
HPRD ID		03750	17888
Ensembl ID		ENSG00000172724	ENSG00000175175
Uniprot IDs		Q6IBD6 Q99731	Q8WY54
PDB IDs		2MP1
Enriched GO Terms of Interacting Partners?
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