CCL7 and ACKR1

Data Source:
HPRD (in vivo)

		CCL7	ACKR1
Description		C-C motif chemokine ligand 7	atypical chemokine receptor 1 (Duffy blood group)
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GO Annotations	Cellular Component	Extracellular Space	Early Endosome Plasma Membrane Integral Component Of Membrane Recycling Endosome
	Molecular Function	Protein Binding Chemokine Activity Heparin Binding CCR1 Chemokine Receptor Binding CCR2 Chemokine Receptor Binding CCR Chemokine Receptor Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity C-C Chemokine Binding Signaling Receptor Activity
	Biological Process	Monocyte Chemotaxis Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Response To Gamma Radiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Eosinophil Chemotaxis Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Ethanol Positive Regulation Of Natural Killer Cell Chemotaxis	Defense Response Inflammatory Response G Protein-coupled Receptor Signaling Pathway Regulation Of Chemokine Production Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines	Peptide ligand-binding receptors
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Crohn's disease ( 28067908 22412388 21102463) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908)	Eotaxin levels ( 27989323) Growth-regulated protein alpha levels ( 27989323) Midgestational total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Monocyte chemoattractant protein-1 levels ( 27989323 31217265) Neutrophil level response to clozapine in treatment-resistant schizophrenia ( 30647433)
Interacting Genes		18 interacting genes: ACKR1 ACKR2 ACKR4 CCR1 CCR10 CCR3 CCR5 CXCL6 FEZ1 MMP1 MMP13 MMP14 MMP2 MMP3 TLE5 UBQLN1 UBQLN2 XCL2	9 interacting genes: CCL17 CCL2 CCL5 CCL7 CCL8 CXCL1 CXCL5 CXCL8 MTNR1B
Entrez ID		6354	2532
HPRD ID		01150	00192
Ensembl ID		ENSG00000108688	ENSG00000213088
Uniprot IDs		P80098	Q16570 Q5Y7A1 Q5Y7A2
PDB IDs		1BO0 1NCV 4ZKC	4NUU 4NUV
Enriched GO Terms of Interacting Partners?
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