CCL2 and CCL11

Data Source:
BioGRID (pull down)

		CCL2	CCL11
Description		C-C motif chemokine ligand 2	C-C motif chemokine ligand 11
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Protein Kinase Activity Signaling Receptor Binding Protein Binding Chemokine Activity CCR2 Chemokine Receptor Binding CCR Chemokine Receptor Binding	Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding Protein Dimerization Activity Receptor Ligand Activity CCR Chemokine Receptor Binding
	Biological Process	MAPK Cascade Angiogenesis Monocyte Chemotaxis Protein Phosphorylation Chemotaxis Inflammatory Response Humoral Immune Response Cytoskeleton Organization Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Shape Response To Bacterium Animal Organ Morphogenesis Viral Genome Replication Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Cellular Homeostasis Neutrophil Chemotaxis Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Helper T Cell Extravasation PERK-mediated Unfolded Protein Response Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Astrocyte Cell Migration Cellular Response To Fibroblast Growth Factor Stimulus Eosinophil Chemotaxis Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of T Cell Activation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Synaptic Transmission, Glutamatergic Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Positive Regulation Of Calcium Ion Import Positive Regulation Of NMDA Glutamate Receptor Activity Negative Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Apoptotic Cell Clearance Negative Regulation Of Natural Killer Cell Chemotaxis	Positive Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Monocyte Chemotaxis Mast Cell Chemotaxis Protein Phosphorylation Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Cytoskeleton Organization Actin Filament Organization Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Learning Or Memory Regulation Of Cell Shape Response To Radiation Response To Virus Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Actin Filament Polymerization Response To Interleukin-13 Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Lymphocyte Chemotaxis Negative Regulation Of Neurogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Chemokine-mediated Signaling Pathway ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-4 Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Modulation Of Age-related Behavioral Decline
Pathways		Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling	Chemokine receptors bind chemokines Interleukin-4 and Interleukin-13 signaling
Drugs		Mimosine Danazol Chondroitin sulfate	CAT-213
Diseases
GWAS		Crohn's disease ( 28067908 22412388 21102463) Gut microbiota (functional units) ( 27694959) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 28067908 23128233)	Crohn's disease ( 28067908 22412388) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908 23128233)
Interacting Genes		28 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL15 CCL26 CCL4L1 CCL5 CCL8 CCR1 CCR10 CCR3 CCR5 CXCL17 CXCL8 CXCL9 MMP1 MMP3 MMP8 PF4 RNF4 SLC16A2 SLC22A1 SLC22A2 TMX2 VCAN XCL2	29 interacting genes: ACKR2 ACKR4 CCL13 CCL14 CCL18 CCL2 CCL26 CCL27 CCL28 CCL5 CCL8 CCR3 CCR5 CXCL1 CXCL10 CXCL11 CXCL12 CXCL14 CXCL2 CXCL3 CXCL5 CXCL6 CXCL9 DPP4 NUDT3 PF4 PF4V1 TPI1 XCL1
Entrez ID		6347	6356
HPRD ID		01149	03098
Ensembl ID		ENSG00000108691	ENSG00000172156
Uniprot IDs		P13500	P51671 Q6I9T4
PDB IDs		1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9	1EOT 2EOT 2MPM
Enriched GO Terms of Interacting Partners?
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