CEACAM1 and ANXA2

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		CEACAM1	ANXA2
Description		CEA cell adhesion molecule 1	annexin A2
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Adherens Junction Basal Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Transport Vesicle Membrane Microvillus Membrane Specific Granule Membrane T Cell Receptor Complex Extracellular Exosome Tertiary Granule Membrane	Extracellular Region Basement Membrane Extracellular Space Nucleus Cytoplasm Lysosomal Membrane Endosome Lipid Droplet Plasma Membrane Adherens Junction Cell Surface Membrane Basolateral Plasma Membrane Midbody Late Endosome Membrane Vesicle Azurophil Granule Lumen Melanosome Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome AnxA2-p11 Complex PCSK9-AnxA2 Complex
	Molecular Function	Molecular_function Actin Binding Protein Binding Calmodulin Binding Bile Acid Transmembrane Transporter Activity Kinase Binding Protein Phosphatase Binding Filamin Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity Protein Tyrosine Kinase Binding	Phosphatidylserine Binding Protease Binding RNA Binding Serine-type Endopeptidase Inhibitor Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Protein Binding Phospholipase A2 Inhibitor Activity Identical Protein Binding S100 Protein Binding Virion Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Angiogenesis Regulation Of Cell Growth Blood Vessel Development Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Negative Regulation Of Protein Kinase Activity Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Integrin-mediated Signaling Pathway Regulation Of Endothelial Cell Migration Regulation Of Phosphatidylinositol 3-kinase Signaling Bile Acid And Bile Salt Transport Cell Migration Regulation Of Cell Migration Negative Regulation Of Granulocyte Differentiation Negative Regulation Of Interleukin-1 Production Cellular Response To Insulin Stimulus Common Myeloid Progenitor Cell Proliferation Insulin Receptor Internalization Granulocyte Colony-stimulating Factor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Neutrophil Degranulation Negative Regulation Of Cytotoxic T Cell Degranulation Wound Healing, Spreading Of Cells Regulation Of Endothelial Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of T Cell Receptor Signaling Pathway Leukocyte Migration Negative Regulation Of Lipid Biosynthetic Process Regulation Of Blood Vessel Remodeling Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Platelet Aggregation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Insulin Catabolic Process Regulation Of Homophilic Cell Adhesion Regulation Of Sprouting Angiogenesis Negative Regulation Of Hepatocyte Proliferation Positive Regulation Of Vasculogenesis	Angiogenesis Membrane Raft Assembly Positive Regulation Of Receptor Recycling Vesicle Budding From Membrane Negative Regulation Of Endopeptidase Activity Viral Process Positive Regulation Of Vesicle Fusion Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Interleukin-12-mediated Signaling Pathway Osteoclast Development Neutrophil Degranulation Positive Regulation Of Vacuole Organization Negative Regulation Of Development Of Symbiont Involved In Interaction With Host Catabolism By Host Of Symbiont Protein Negative Regulation By Host Of Symbiont Molecular Function Calcium Ion Transmembrane Transport Cell-cell Adhesion Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Low-density Lipoprotein Receptor Activity Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Pathways		Fibronectin matrix formation Cell surface interactions at the vascular wall Neutrophil degranulation	Smooth Muscle Contraction Neutrophil degranulation Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Technetium Tc-99m arcitumomab	Tenecteplase Fluocinolone acetonide Lanoteplase Artenimol
Diseases
GWAS			Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576 28240269) Night sleep phenotypes ( 27126917) Type 2 diabetes ( 25102180)
Interacting Genes		18 interacting genes: ADRB2 ANXA2 CARTPT CD209 CEACAM3 CEACAM5 CEACAM6 CEACAM7 CEACAM8 EGFR FLNA INSR MAP3K10 PTPN11 PTPN6 PXN SHC1 SRC	44 interacting genes: ACTA1 APOH APP CCDC32 CD99 CDC42 CEACAM1 CTSB CTSS DYSF GRB2 HMGA1 LGALS13 LINC01554 LYPLA1 MAP3K4 MYOC NOD2 OGDH PHB PLA1A PLA2G4A PLAT PLG POT1 PRKCA PRKCB PTEN RPS2 S100A10 S100A4 S100A6 SMN1 SNX17 SOS1 SRC STAT6 TENT2 TERF1 TERT TP53 TRPV5 YWHAQ ZBTB4
Entrez ID		634	302
HPRD ID		00191	01061
Ensembl ID		ENSG00000079385	ENSG00000182718
Uniprot IDs		P13688 Q3KRG8	A0A024R5Z7 P07355
PDB IDs		2GK2 4QXW 4WHD 5DZL 6AW2 6GBG 6GBH	1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4FTG 4HRH 5LPU 5LPX 5LQ0 5LQ2 5N7D 5N7F 5N7G 6TWQ 6TWU 6TWX 6TWY
Enriched GO Terms of Interacting Partners?
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