SCN2A and PKP4

Data Source:
HPRD (in vivo)

		SCN2A	PKP4
Description		sodium voltage-gated channel alpha subunit 2	plakophilin 4
Image			No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Membrane T-tubule Axon Intrinsic Component Of Plasma Membrane Node Of Ranvier Paranode Region Of Axon Sodium Channel Complex Glutamatergic Synapse Integral Component Of Presynaptic Membrane	Spindle Pole Cornified Envelope Nucleus Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Cytoplasmic Side Of Plasma Membrane Cell Junction Desmosome Midbody Cell-cell Contact Zone Perinuclear Region Of Cytoplasm Spindle Midzone Mitotic Spindle
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity	Protein Binding Cadherin Binding
	Biological Process	Sodium Ion Transport Nervous System Development Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuron Apoptotic Process Cellular Response To Hypoxia Membrane Depolarization During Action Potential	Cell-cell Junction Assembly Cell-cell Signaling Regulation Of Cell Adhesion Keratinization Positive Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Cornification Cell-cell Adhesion
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	Keratinization Formation of the cornified envelope
Drugs		Tramadol Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Metergoline Bioallethrin Amylmetacresol Fish oil
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Adult body size ( 32376654) Bipolar disorder ( 31043756) Diastolic blood pressure ( 30224653) Epilepsy ( 30531953) Factor VII activity ( 30642921) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Febrile seizures (MMR vaccine-unrelated) ( 25344690) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Trunk fat mass ( 28552196) Urinary sodium excretion ( 31409800)	Borderline personality disorder ( 28632202) Obesity-related traits ( 23251661) Restless legs syndrome ( 29029846)
Interacting Genes		5 interacting genes: ANK3 ARHGEF10L MPP3 RNF130 SCN4B	19 interacting genes: ATPAF2 CDH1 CDH2 CDH5 DSC3 DSP ERBIN GABARAP GOLGA2 LNX1 LZTS2 MINK1 OSGEP PAXIP1 PDZD2 PGAM1 PSEN1 TRIM23 UBASH3B
Entrez ID		6326	8502
HPRD ID		03133	05043
Ensembl ID		ENSG00000136531	ENSG00000144283
Uniprot IDs		Q99250	Q99569
PDB IDs		2KAV 4JPZ 4RLY 6BUT 6J8E
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?