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RXRB and THRA
Data Source:
HPRD
(in vitro)
RXRB
THRA
Description
retinoid X receptor beta
thyroid hormone receptor alpha
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
RNA Polymerase II Transcription Regulator Complex
Chromatin
Nucleus
Nucleoplasm
Cytosol
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Retinoic Acid-responsive Element Binding
Sequence-specific Double-stranded DNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
TBP-class Protein Binding
Protein Domain Specific Binding
Chromatin DNA Binding
Protein-containing Complex Binding
Thyroid Hormone Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Cell Differentiation
Response To Retinoic Acid
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Retinoic Acid Receptor Signaling Pathway
Anatomical Structure Development
Negative Regulation Of Transcription By RNA Polymerase II
Cartilage Condensation
Ossification
Thyroid Hormone Mediated Signaling Pathway
Regulation Of Thyroid Hormone Mediated Signaling Pathway
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Learning Or Memory
Regulation Of Heart Contraction
Female Courtship Behavior
Response To Cold
Hormone-mediated Signaling Pathway
Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Cell Differentiation
Erythrocyte Differentiation
Thyroid Gland Development
Regulation Of Myeloid Cell Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Female Receptivity
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Lipid Catabolic Process
Type I Pneumocyte Differentiation
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of DNA-templated Transcription, Initiation
Pathways
PPARA activates gene expression
Nuclear Receptor transcription pathway
Signaling by Retinoic Acid
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Nuclear Receptor transcription pathway
Drugs
Adapalene
Bexarotene
Rosiglitazone
Acitretin
Alitretinoin
Tretinoin
Tazarotene
Etretinate
Bezafibrate
LG-100268
Phthalic Acid
Doconexent
TO-901317
N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE
(2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID
Liothyronine
Levothyroxine
Dextrothyroxine
Amiodarone
Liotrix
KB-141
Dronedarone
Eprotirome
NRP409
Thyroid, porcine
Diseases
GWAS
Wegener's granulomatosis (
23740775
)
Asthma (
31619474
)
Bipolar disorder (
31043756
)
Chronic obstructive pulmonary disease (
30804561
)
Pancreatic ductal adenocarcinoma (
30541042
)
White blood cell count (
21738480
)
Interacting Genes
48 interacting genes:
AKAP13
CACNA1B
CALCOCO2
CCDC57
EXOSC8
GOLGA2
GTF2H1
KRT40
MAP4
MID2
MYG1
NCOA1
NCOA3
NR0B2
NR1H2
NR1H3
NR1H4
NR1I2
NR2C2
NR2E3
NR3C1
NR4A2
NRIP1
PICK1
PLSCR1
PPARD
PPARG
PSTPIP1
PTMS
RARA
RARB
RARG
SIAH1
SPOP
SPOPL
TACC2
TADA3
TAF11
TFCP2
TFIP11
THRA
THRB
TP53BP2
TRIM27
TRIM37
UBL7
VDR
ZDHHC12
69 interacting genes:
-
AKAP13
AMOT
AMOTL2
ARID5A
BTG1
BUB3
C1D
CCND1
CD160
CDK7
CEP76
CLIC1
COPS2
CREB1
CREBBP
CUL1
DAP3
ESR1
FOXJ1
FUS
GRIP1
GTF2B
HDAC2
HDAC3
ITGB3BP
L3MBTL3
MED1
MED21
MED25
MEF2A
MEOX2
MTNR1B
NCOA1
NCOA2
NCOA6
NCOR1
NCOR2
NR0B2
NR2F1
NRIP1
NSD1
OASL
PML
POU2F1
PRKAR1B
PRKDC
PTGES3
RANBP9
RGN
RXRA
RXRB
RXRG
SELENOP
SLC16A2
SRC
SUV39H1
SYAP1
TACC1
TBL1X
TDG
TRIM24
TRIM63
TRIP11
TXNRD1
UBE2I
YWHAH
YWHAQ
ZBTB3
Entrez ID
6257
7067
HPRD ID
01578
07185
Ensembl ID
ENSG00000204231
ENSG00000126351
Uniprot IDs
A0A0G2JKR7
A0A0S2Z570
B7Z7J5
P28702
Q5STP9
P10827
Q6FH41
PDB IDs
1H9U
1UHL
5HJP
5I4V
5KYA
5KYJ
7A78
1NAV
2H77
2H79
3HZF
3ILZ
3JZB
4LNW
4LNX
Enriched GO Terms of Interacting Partners
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