RRM1 and RNH1

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		RRM1	RNH1
Description		ribonucleotide reductase catalytic subunit M1	ribonuclease/angiogenin inhibitor 1
Image
GO Annotations	Cellular Component	Nuclear Envelope Cytosol Ribonucleoside-diphosphate Reductase Complex Cell Projection Neuronal Cell Body	Nucleoplasm Cytosol Angiogenin-PRI Complex Extracellular Exosome
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding	Protein Binding Ribonuclease Inhibitor Activity
	Biological Process	Mitotic Cell Cycle Pyrimidine Nucleobase Metabolic Process DNA Replication Male Gonad Development Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Nucleobase-containing Small Molecule Interconversion Cell Proliferation In Forebrain Protein Heterotetramerization Retina Development In Camera-type Eye	MRNA Catabolic Process Negative Regulation Of Catalytic Activity Regulation Of Angiogenesis
Pathways		Interconversion of nucleotide di- and triphosphates
Drugs		Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon Gallium maltolate Tezacitabine
Diseases
GWAS		Malaria ( 31844061) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414)	Body mass index ( 25673413) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494)
Interacting Genes		10 interacting genes: BMI1 CDC42 LRIF1 PPP1CC RNF2 RRM2 RRM2B SUMO2 YWHAG ZNF655	3 interacting genes: ANG RNASE1 SDCBP
Entrez ID		6240	6050
HPRD ID		01588	01412
Ensembl ID		ENSG00000167325	ENSG00000023191
Uniprot IDs		B4DXD1 B4E0I8 E9PL69 P23921	A0A140VJT8 P13489
PDB IDs		2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI 6L3R 6L7L	1A4Y 1Z7X 2BEX 2Q4G
Enriched GO Terms of Interacting Partners?
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