RPS14 and PEX6

Data Source:
BioGRID (two hybrid)

		RPS14	PEX6
Description		ribosomal protein S14	peroxisomal biogenesis factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytosol Focal Adhesion Postsynaptic Density Membrane Cytosolic Small Ribosomal Subunit Extracellular Exosome	Photoreceptor Outer Segment Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Photoreceptor Cell Cilium
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding Translation Regulator Activity MRNA 5'-UTR Binding Small Ribosomal Subunit RRNA Binding	Protein Binding ATP Binding Protein C-terminus Binding ATPase Activity Protein-containing Complex Binding
	Biological Process	Ribosomal Small Subunit Assembly Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Translation Translational Initiation Regulation Of Translation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Erythrocyte Differentiation Maturation Of SSU-rRNA	Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Translocation Protein Stabilization
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Alzheimer's disease in APOE e4+ carriers ( 25778476) Hematocrit ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		10 interacting genes: APP CALM1 DUX4 KRR1 PEX6 RBBP6 RLIM SMAD2 TAF9 TMEM33	8 interacting genes: ATF7IP CERS2 PEX1 PEX26 PEX5 RPL27A RPS14 SMAD3
Entrez ID		6208	5190
HPRD ID		00562	03293
Ensembl ID		ENSG00000164587	ENSG00000124587
Uniprot IDs		P62263	A0A024RD09 Q13608
PDB IDs		4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBD 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZVH 7A09 7K5I
Enriched GO Terms of Interacting Partners?
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