RPS6KA2 and KCNJ6

Data Source:
BioGRID (affinity chromatography technology)

		RPS6KA2	KCNJ6
Description		ribosomal protein S6 kinase A2	potassium inwardly rectifying channel subfamily J member 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Golgi Apparatus Plasma Membrane Voltage-gated Potassium Channel Complex
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK	Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Ethanol Halothane Ifenprodil Isavuconazole
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alzheimer's disease progression score ( 29860282) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Blood pressure (smoking interaction) ( 25189868) Dental caries ( 23259602) Inflammatory bowel disease ( 27569725 23128233) Pre-treatment viral load in HIV-1 infection ( 31219150) Smooth-surface caries ( 24556642) Urinary metabolite levels in chronic kidney disease ( 31959995) Waist circumference ( 28552196)	Body size at age 10 ( 32376654) Electroencephalographic traits in alcoholism ( 22554406) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Rosacea symptom severity ( 29771307)
Interacting Genes		12 interacting genes: BAD CREB1 FLNC FOS JUN L1CAM MAGI1 MAP2K1 MAPK1 MAPK3 SHANK1 TP53	63 interacting genes: ADRB2 AIG1 APOD BCL2L2 BET1 BIRC5 C14orf180 CMTM5 CNPY3 COL4A5 DLG1 DRD2 EDDM3B ERG28 FAM20B FIS1 FUNDC2 FXYD6 GABBR1 HMOX2 ICMT ITGAM KCNJ3 KCNJ9 LEPROTL1 LPAR3 LPCAT2 MIP MYO15B NINJ2 ORMDL2 PEX11G PEX16 PLLP PMP22 PNLIPRP1 RPRM RTP2 SCAMP4 SCARF1 SCD SERTM1 STATH STRIT1 SYT3 THSD7B TM6SF2 TMEM107 TMEM120B TMEM203 TMEM208 TMEM218 TMPPE TNFRSF10C TSPO2 UBIAD1 UNC50 UPK1B VSTM1 XIAP YIPF1 YIPF6 ZDHHC24
Entrez ID		6196	3763
HPRD ID		03403	02929
Ensembl ID		ENSG00000071242	ENSG00000157542
Uniprot IDs		B7Z3B5 Q15349 X5D337	P48051
PDB IDs
Enriched GO Terms of Interacting Partners?
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