KCNJ6 and ORMDL2

Data Source:
BioGRID (two hybrid)

		KCNJ6	ORMDL2
Description		potassium inwardly rectifying channel subfamily J member 6	ORMDL sphingolipid biosynthesis regulator 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Voltage-gated Potassium Channel Complex	Endoplasmic Reticulum Integral Component Of Membrane SPOTS Complex
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity	Protein Binding
	Biological Process	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Ceramide Metabolic Process Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process
Pathways		Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Sphingolipid de novo biosynthesis
Drugs		Ethanol Halothane Ifenprodil Isavuconazole
Diseases
GWAS		Body size at age 10 ( 32376654) Electroencephalographic traits in alcoholism ( 22554406) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Rosacea symptom severity ( 29771307)	Refractive error ( 32231278)
Interacting Genes		63 interacting genes: ADRB2 AIG1 APOD BCL2L2 BET1 BIRC5 C14orf180 CMTM5 CNPY3 COL4A5 DLG1 DRD2 EDDM3B ERG28 FAM20B FIS1 FUNDC2 FXYD6 GABBR1 HMOX2 ICMT ITGAM KCNJ3 KCNJ9 LEPROTL1 LPAR3 LPCAT2 MIP MYO15B NINJ2 ORMDL2 PEX11G PEX16 PLLP PMP22 PNLIPRP1 RPRM RTP2 SCAMP4 SCARF1 SCD SERTM1 STATH STRIT1 SYT3 THSD7B TM6SF2 TMEM107 TMEM120B TMEM203 TMEM208 TMEM218 TMPPE TNFRSF10C TSPO2 UBIAD1 UNC50 UPK1B VSTM1 XIAP YIPF1 YIPF6 ZDHHC24	21 interacting genes: AQP6 CD79A CREB3L1 CYB561 CYB5R3 DAPK1 EBP ELOVL4 FAM210B FCER1G GJA8 KCNJ6 MMGT1 RETREG3 SCN3B SLC10A1 TMEM120A TMEM31 TMEM86B TMX2 ZDHHC15
Entrez ID		3763	29095
HPRD ID		02929	17802
Ensembl ID		ENSG00000157542	ENSG00000123353
Uniprot IDs		P48051	Q53FV1
PDB IDs
Enriched GO Terms of Interacting Partners?
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