RORA and BHLHE41

Data Source:
BioGRID (two hybrid)

		RORA	BHLHE41
Description		RAR related orphan receptor A	basic helix-loop-helix family member e41
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Oxysterol Binding Zinc Ion Binding Sequence-specific DNA Binding Ligand-activated Transcription Factor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Angiogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Regulation Of Smoothened Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Cytokine-mediated Signaling Pathway Cerebellar Purkinje Cell Differentiation Cerebellar Granule Cell Precursor Proliferation Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Sterol Cholesterol Homeostasis Muscle Cell Differentiation Positive Regulation Of Circadian Rhythm Regulation Of Macrophage Activation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II CGMP Metabolic Process Negative Regulation Of Inflammatory Response Triglyceride Homeostasis Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia T-helper 17 Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Negative Regulation Of Myotube Differentiation Negative Regulation Of Transcription By Competitive Promoter Binding Circadian Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis
Pathways		RORA activates gene expression PPARA activates gene expression Nuclear Receptor transcription pathway Circadian Clock SUMOylation of intracellular receptors Interleukin-4 and Interleukin-13 signaling	BMAL1:CLOCK,NPAS2 activates circadian gene expression Circadian Clock
Drugs		Cholesterol sulfate Cholesterol
Diseases
GWAS		Adult asthma ( 30787307) Adult body size ( 32376654) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184) Apolipoprotein A1 levels ( 32203549) Asthma ( 31361310 31959851 30929738 20860503 27182965 32296059 31619474 29273806) Asthma (adult onset) ( 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Birth weight ( 31043758) Blood protein levels ( 28240269) Blood urea nitrogen levels ( 31152163 29403010) Body mass index ( 28892062) Breast cancer (prognosis) ( 23319801) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Chronic central serous retinopathy ( 30073298) Depression (quantitative trait) ( 20800221) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Gamma glutamyl transferase levels ( 22010049) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 31211820) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 29617998) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Male-pattern baldness ( 28196072) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Menarche (age at onset) ( 21102462 23599027 25231870) Multiple sclerosis ( 31604244) Neuropathic pain in head and neck cancer ( 29884837) Nickel levels ( 26025379) Offspring birth weight ( 31043758) Pulmonary function decline ( 22424883) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to citalopram treatment ( 19846067) Reticulocyte count ( 32888494) Schizophrenia ( 23212062) Subcutaneous adipose tissue ( 22589738) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) Triglyceride levels ( 32203549 32154731)	Response to bupropion and depression ( 27622933) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		23 interacting genes: BHLHE41 COPS5 CSNK1E EP300 GFAP HIF1A LMO3 LRIF1 MED1 MYOD1 NCOA1 NCOA2 NME1 NME2 NR0B1 NSD1 PNRC1 PNRC2 PROX1 PSMC5 SMARCD3 SP1 ZXDC	22 interacting genes: BHLHE40 CLOCK CRY1 CRY2 CSNK1E CSNK2A1 CSNK2A2 CSNK2B DELEC1 FBXW11 GSK3B MYOD1 NONO PER2 PPP2CB PPP2R1B PPP2R5E RASD1 RORA RORC SIRT1 WDR5
Entrez ID		6095	79365
HPRD ID		02896	16204
Ensembl ID		ENSG00000069667	ENSG00000123095
Uniprot IDs		A0A0C4DFP5 A0A0C4DG53 P35398	A0A024RAV8 Q8TAT1 Q9C0J9
PDB IDs		1N83 1S0X 4S15
Enriched GO Terms of Interacting Partners?
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