RNH1 and RRM1

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		RNH1	RRM1
Description		ribonuclease/angiogenin inhibitor 1	ribonucleotide reductase catalytic subunit M1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Angiogenin-PRI Complex Extracellular Exosome	Nuclear Envelope Cytosol Ribonucleoside-diphosphate Reductase Complex Cell Projection Neuronal Cell Body
	Molecular Function	Protein Binding Ribonuclease Inhibitor Activity	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding
	Biological Process	MRNA Catabolic Process Negative Regulation Of Catalytic Activity Regulation Of Angiogenesis	Mitotic Cell Cycle Pyrimidine Nucleobase Metabolic Process DNA Replication Male Gonad Development Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Nucleobase-containing Small Molecule Interconversion Cell Proliferation In Forebrain Protein Heterotetramerization Retina Development In Camera-type Eye
Pathways			Interconversion of nucleotide di- and triphosphates
Drugs			Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon Gallium maltolate Tezacitabine
Diseases
GWAS		Body mass index ( 25673413) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494)	Malaria ( 31844061) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414)
Interacting Genes		3 interacting genes: ANG RNASE1 SDCBP	10 interacting genes: BMI1 CDC42 LRIF1 PPP1CC RNF2 RRM2 RRM2B SUMO2 YWHAG ZNF655
Entrez ID		6050	6240
HPRD ID		01412	01588
Ensembl ID		ENSG00000023191	ENSG00000167325
Uniprot IDs		A0A140VJT8 P13489	B4DXD1 B4E0I8 E9PL69 P23921
PDB IDs		1A4Y 1Z7X 2BEX 2Q4G	2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI 6L3R 6L7L
Enriched GO Terms of Interacting Partners?
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