PPCDC and CENPT

Data Source:
HPRD (two hybrid)

		PPCDC	CENPT
Description		phosphopantothenoylcysteine decarboxylase	centromere protein T
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Phosphopantothenoylcysteine Decarboxylase Complex	Chromosome, Centromeric Region Kinetochore Condensed Nuclear Chromosome Kinetochore Nucleoplasm Cytosol Nuclear Body
	Molecular Function	Phosphopantothenoylcysteine Decarboxylase Activity Protein Binding FMN Binding Identical Protein Binding	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Coenzyme A Biosynthetic Process	Mitotic Cell Cycle Chromosome Segregation CENP-A Containing Nucleosome Assembly Chromosome Organization Cell Division Kinetochore Assembly Protein Localization To Kinetochore Involved In Kinetochore Assembly
Pathways		Coenzyme A biosynthesis	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Flavin mononucleotide Pantothenoylaminoethenethiol
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Apolipoprotein A1 levels ( 32203549) Blood trace element (Zn levels) ( 23720494) Caffeine consumption ( 21490707) Coffee consumption (cups per day) ( 31837886) Heel bone mineral density ( 30598549) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systemic lupus erythematosus ( 26502338) White blood cell count ( 32888494)	Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		13 interacting genes: CENPT DBI DDIT4L FOXR1 NAA80 NTAQ1 PLEKHF2 PPIG PSMA1 SREK1IP1 TXN2 UBE2I ZNF232	8 interacting genes: APP CENPW COPS5 DHX29 H3C1 PPCDC SNCB TCEA2
Entrez ID		60490	80152
HPRD ID		14377	07811
Ensembl ID		ENSG00000138621	ENSG00000102901
Uniprot IDs		H3BQB0 H3BRQ0 H3BSE3 H3BU63 Q96CD2	B3KPB2 Q96BT3
PDB IDs		1QZU
Enriched GO Terms of Interacting Partners?
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