RFC4 and BRD4

Data Source:
HPRD (in vitro, in vivo)

		RFC4	BRD4
Description		replication factor C subunit 4	bromodomain containing 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Ctf18 RFC-like Complex Elg1 RFC-like Complex	Condensed Nuclear Chromosome Nucleus Nucleoplasm
	Molecular Function	DNA Clamp Loader Activity Protein Binding ATP Binding Single-stranded DNA Helicase Activity	P53 Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Enzyme Binding Lysine-acetylated Histone Binding RNA Polymerase II C-terminal Domain Binding P-TEFb Complex Binding
	Biological Process	DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication DNA Duplex Unwinding Nucleotide-excision Repair, DNA Incision Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Error-free Translesion Synthesis Positive Regulation Of DNA-directed DNA Polymerase Activity Regulation Of Signal Transduction By P53 Class Mediator	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Chromatin Organization Protein Phosphorylation Cellular Response To DNA Damage Stimulus Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Positive Regulation Of Histone H3-K36 Trimethylation
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint	Potential therapeutics for SARS
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881)	Immature fraction of reticulocytes ( 32888494) Mean reticulocyte volume ( 32888494) Platelet count ( 32888494) Red cell distribution width ( 32888494) Systolic blood pressure ( 30578418)
Interacting Genes		13 interacting genes: BRD4 CDK4 CHTF18 HDAC1 PCNA PTEN RAD17 RFC2 RFC3 RFC5 RNF41 SUMO2 TRIM28	17 interacting genes: C7orf25 C8orf33 CCNT1 CCNT2 CHFR CLDN1 COPS5 H3C14 H4-16 H4C14 MESD PRPF40A RFC1 RFC4 TRIM55 TRIM63 USP17L2
Entrez ID		5984	23476
HPRD ID		00022	10574
Ensembl ID		ENSG00000163918	ENSG00000141867
Uniprot IDs		P35249	A0A024R7H8 O60885
PDB IDs		6VVO	2I8N 2LSP 2MJV 2N3K 2NCZ 2ND0 2ND1 2NNU 2OSS 2OUO 2YEL 2YEM 3MXF 3P5O 3SVF 3SVG 3U5J 3U5K 3U5L 3UVW 3UVX 3UVY 3UW9 3ZYU 4A9L 4BJX 4BW1 4BW2 4BW3 4BW4 4C66 4C67 4CFK 4CFL 4CL9 4CLB 4DON 4E96 4F3I 4GPJ 4HBV 4HBW 4HBX 4HBY 4HXK 4HXL 4HXM 4HXN 4HXO 4HXP 4HXR 4HXS 4IOO 4IOQ 4IOR 4J0R 4J0S 4J3I 4KV1 4KV4 4LR6 4LRG 4LYI 4LYS 4LYW 4LZR 4LZS 4MEN 4MEO 4MEP 4MEQ 4MR3 4MR4 4NQM 4NR8 4NUC 4NUD 4NUE 4O70 4O71 4O72 4O74 4O75 4O76 4O77 4O78 4O7A 4O7B 4O7C 4O7E 4O7F 4OGI 4OGJ 4PCE 4PCI 4PS5 4QB3 4QR3 4QR4 4QR5 4QZS 4UIX 4UIY 4UIZ 4UYD 4WHW 4WIV 4X2I 4XY9 4XYA 4YH3 4YH4 4Z1Q 4Z1S 4Z93 4ZC9 4ZW1 5A5S 5A85 5ACY 5AD2 5AD3 5BT4 5CFW 5COI 5CP5 5CPE 5CQT 5CRM 5CRZ 5CS8 5CTL 5CY9 5D0C 5D24 5D25 5D26 5D3H 5D3J 5D3L 5D3N 5D3P 5D3R 5D3S 5D3T 5DLX 5DLZ 5DW2 5DX4 5E0R 5EGU 5EI4 5EIS 5F5Z 5F60 5F61 5F62 5F63 5FBX 5H21 5HCL 5HLS 5HM0 5HQ5 5HQ6 5HQ7 5I80 5I88 5IGK 5JWM 5KDH 5KHM 5KJ0 5KU3 5LJ1 5LJ2 5LRQ 5LUU 5M39 5M3A 5MKZ 5MLI 5N2M 5NNC 5NND 5NNE 5NNF 5NNG 5O97 5OVB 5OWM 5OWW 5T35 5TI2 5TI3 5TI4 5TI5 5TI6 5TI7 5U28 5U2C 5U2E 5U2F 5UEO 5UEP 5UEQ 5UER 5UES 5UET 5UEU 5UEV 5UEX 5UEY 5UEZ 5UF0 5ULA 5UOO 5UVS 5UVT 5UVU 5UVV 5UVW 5UVX 5UVY 5UVZ 5V67 5VBO 5VBP 5VOM 5VZS 5W55 5WA5 5WMA 5WMD 5WMG 5WUU 5XHY 5XI2 5XI3 5XI4 5Y1Y 5Y8C 5Y8W 5Y8Y 5Y8Z 5Y93 5Y94 5YOU 5YOV 5YQX 5Z1R 5Z1S 5Z1T 5Z5T 5Z5U 5Z5V 5Z8G 5Z8R 5Z8Z 5Z90 5Z9C 5Z9K 6AFR 6AJV 6AJW 6AJX 6AJY 6AJZ 6BN7 6BN8 6BN9 6BNB 6BNH 6BOY 6C7Q 6C7R 6CD4 6CD5 6CIS 6CIY 6CJ1 6CJ2 6CKR 6CKS 6CZU 6CZV 6DJC 6DL2 6DMJ 6DML 6DNE 6DUV 6E4A 6FFD 6FNX 6FO5 6FSY 6FT3 6FT4 6G0D 6G0E 6G0F 6G0G 6G0H 6G0O 6G0P 6G0Q 6G0R 6G0S 6HDQ 6HOV 6I7X 6I7Y 6IN1 6JI3 6JI4 6JI5 6JJ3 6JJ5 6JJ6 6JJB 6KEC 6KED 6KEE 6KEF 6KEG 6KEH 6KEI 6KEJ 6KEK 6KO2 6MAU 6MH1 6MH7 6MNL 6P05 6PRT 6PS9 6PSB 6Q3Y 6Q3Z 6S25 6SE4 6SIS 6SWN 6SWQ 6TPX 6TPY 6TPZ 6U0D 6U6K 6U6L 6U72 6U74 6U8G 6U8I 6U8M 6ULS 6UVJ 6UVM 6UWU 6UWX 6V0U 6V1K 6V1L 6V1U 6VIW 6VIX 6VIZ 6VUB 6VUC 6VUF 6VUJ 6WGX 6WW8 6X7B 6X7C 6X7D 6XUZ 6XV3 6XV7 6XVC 6YIN 6YQN 6YQO 6YQP 6Z7G 6Z7L 6Z7M 6ZB3 6ZED 6ZEL 6ZF9 7A9U
Enriched GO Terms of Interacting Partners?
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