ALOXE3 and YY1

Data Source:
BioGRID (two hybrid)

		ALOXE3	YY1
Description		arachidonate lipoxygenase 3	YY1 transcription factor
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Transcription Regulator Complex Chromatin Silencing Complex Cytoplasm Nuclear Matrix Ino80 Complex PcG Protein Complex
	Molecular Function	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Intramolecular Transferase Activity, Transferring Hydroxy Groups Hepoxilin A3 Synthase Activity Hydroperoxy Icosatetraenoate Isomerase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity	Four-way Junction DNA Binding Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding RNA Binding Protein Binding SMAD Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Sphingolipid Metabolic Process Sensory Perception Of Pain Arachidonic Acid Metabolic Process Lipoxygenase Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Linoleic Acid Metabolic Process Fat Cell Differentiation Ceramide Biosynthetic Process Hepoxilin Biosynthetic Process Establishment Of Skin Barrier	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Regulation Of Transcription By RNA Polymerase II RNA Localization Cellular Response To DNA Damage Stimulus Spermatogenesis Anterior/posterior Pattern Specification Response To UV-C Negative Regulation Of Gene Expression Protein Deubiquitination B Cell Differentiation Negative Regulation Of Interferon-beta Production Cellular Response To UV Response To Prostaglandin F Positive Regulation Of Transcription By RNA Polymerase II Cell Development Camera-type Eye Morphogenesis Chromosome Organization Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Interleukin-1 Immunoglobulin Heavy Chain V-D-J Recombination Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways		Synthesis of 12-eicosatetraenoic acid derivatives	Activation of anterior HOX genes in hindbrain development during early embryogenesis UCH proteinases DNA Damage Recognition in GG-NER TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Estrogen-dependent gene expression
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS			Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Pulse pressure ( 30224653)
Interacting Genes		2 interacting genes: YY1 ZNF76	90 interacting genes: ALOXE3 APP ATF2 ATF6 ATF7 AURKA BAP1 BCCIP BRCA1 CDKN2A CEP76 CREB1 CRKL CYSRT1 DNMT3L E2F2 E2F3 EED EP300 ESM1 FHL2 FKBP1A FKBP3 GMCL1 GRN GTF2I HCFC1 HDAC2 HDAC3 HOXA11 IL10 INO80 KAT2B KRTAP1-3 KRTAP1-5 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP4-2 KRTAP4-5 KRTAP5-6 KRTAP9-3 KRTAP9-8 LHX3 LHX4 MDFI MED20 MTA2 MYC NEDD4L NFKB1 NOTCH1 NPM1 NR1H2 PLEKHF2 PPIA PSMD9 RAF1 RUVBL1 RUVBL2 RYBP SAP30 SF3A2 SKP2 SLC39A7 SMAD1 SMAD2 SMAD3 SMURF2 SP1 SPRY1 SREBF1 TESK1 TFCP2 TP53 TRIM42 TWIST1 UHRF2 VWC2 XAGE1A XAGE1B YAF2 ZNF232 ZNF85 ZRANB2
Entrez ID		59344	7528
HPRD ID		06231	02482
Ensembl ID		ENSG00000179148	ENSG00000100811
Uniprot IDs		Q9BYJ1	P25490
PDB IDs			1UBD 1ZNM 4C5I
Enriched GO Terms of Interacting Partners?
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