IL21 and DGKA

Data Source:
HPRD (in vivo)

		IL21	DGKA
Description		interleukin 21	diacylglycerol kinase alpha
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytosol Plasma Membrane Membrane
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Interleukin-2 Receptor Binding Protein Binding	NAD+ Kinase Activity Diacylglycerol Kinase Activity Calcium Ion Binding ATP Binding Phospholipid Binding Lipid Binding Kinase Activity
	Biological Process	Positive Regulation Of Cytokine Production Germinal Center B Cell Differentiation Immunoglobulin Production Signal Transduction Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cell Population Proliferation Positive Regulation Of B Cell Proliferation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tissue Remodeling Interleukin-21-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Maturation Positive Regulation Of Inflammatory Response Defense Response To Virus T Follicular Helper Cell Differentiation Cellular Response To Virus	Phosphatidic Acid Biosynthetic Process Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation
Pathways		Interleukin-21 signaling	Effects of PIP2 hydrolysis
Drugs			Vitamin E alpha-Tocopherol succinate
Diseases		Type I diabetes mellitus
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Alopecia areata ( 20596022 25608926) Alzheimer's disease in APOE e4- carriers ( 25778476) Asthma ( 31959851 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825 26482879 23727859) Bipolar disorder ( 31043756) Celiac disease ( 22057235 20190752 17558408 24999842 18311140) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mosquito bite size ( 28199695) Night sleep phenotypes ( 27126917) Pediatric autoimmune diseases ( 26301688) Primary biliary cholangitis ( 28425483) Primary sclerosing cholangitis ( 23603763 27992413) Progressive supranuclear palsy ( 21685912) Rheumatoid arthritis ( 30423114 24390342 20453842) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 25751624) Ulcerative colitis ( 21297633) Vaso-occlusive pain in sickle-cell anemia ( 28584135)	Anorexia nervosa ( 28494655) Refractive error ( 32231278) Vitiligo ( 22951725)
Interacting Genes		4 interacting genes: ASPH DGKA FBXO25 IL21R	3 interacting genes: IL21 SRC SREK1
Entrez ID		59067	1606
HPRD ID		05650	00517
Ensembl ID		ENSG00000138684	ENSG00000065357
Uniprot IDs		A0A224B028 Q9HBE4	A0A024RB23 P23743
PDB IDs		2OQP 3TGX	1TUZ 6IIE
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?