RAB5C and RAPGEFL1

Data Source:
BioGRID (affinity chromatography technology)

		RAB5C	RAPGEFL1
Description		RAB5C, member RAS oncogene family	Rap guanine nucleotide exchange factor like 1
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GO Annotations	Cellular Component	Lysosomal Membrane Endosome Early Endosome Lipid Droplet Plasma Membrane Endomembrane System Endocytic Vesicle Early Endosome Membrane Azurophil Granule Membrane Melanosome Extracellular Exosome	Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Intracellular Protein Transport Endocytosis Regulation Of Endocytosis Neutrophil Degranulation Plasma Membrane To Endosome Transport	G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Nervous System Development Regulation Of Catalytic Activity
Pathways		Golgi Associated Vesicle Biogenesis Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Fibrinogen levels ( 28107422 26561523) Mean corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737) White blood cell count ( 32888494)	Asthma ( 31619474) HDL cholesterol levels ( 32203549) Monocyte percentage of white cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		15 interacting genes: ALS2CL APP APPL2 EEA1 ERBB2 GLP1R HRAS INCA1 RABAC1 RBSN RIN2 RIN3 SGSM3 TBC1D15 TBC1D17	2 interacting genes: APP MLH1
Entrez ID		5878	51195
HPRD ID		04947	17954
Ensembl ID		ENSG00000108774	ENSG00000108352
Uniprot IDs		A0A024R1U4 P51148	B4DGK9 F5H2D5 Q9UHV5
PDB IDs		4KYI	2DHZ
Enriched GO Terms of Interacting Partners?
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