SRPRB and CDK5RAP3

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid)

		SRPRB	CDK5RAP3
Description		SRP receptor subunit beta	CDK5 regulatory subunit associated protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Signal Recognition Particle Receptor Complex Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Membrane Integral Component Of Membrane	Nucleus Nucleolus Cytoplasm Centrosome Cytosol Microtubule Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	GTP Binding	Protein Binding Protein Kinase Binding Cyclin Binding Ubiquitin-like Protein Ligase Binding Mitogen-activated Protein Kinase Binding NF-kappaB Binding MDM2/MDM4 Family Protein Binding
	Biological Process	IRE1-mediated Unfolded Protein Response Protein Targeting To ER	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Liver Development Negative Regulation Of Protein Phosphorylation Mitotic G2 DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Brain Development Cell Population Proliferation Regulation Of Phosphatase Activity Viral Process Apoptotic Nuclear Changes Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Endoplasmic Reticulum Stress Negative Regulation Of MAP Kinase Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Mitotic G2/M Transition Checkpoint Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Definitive Erythrocyte Differentiation Protein Ufmylation Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		SRP-dependent cotranslational protein targeting to membrane XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) Blood protein levels ( 29875488) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Nicotine dependence symptom count ( 25555482) Red blood cell count ( 32888494)	Adult body size ( 32376654) Body mass index ( 26426971) Generalized epilepsy ( 22949513) Metabolite levels (Pyroglutamine) ( 23934736)
Interacting Genes		3 interacting genes: CDK5RAP3 RCHY1 UBC	13 interacting genes: CDK5R1 CREBBP CRMP1 DISC1 ESS2 FKBP6 HSPB1 KPNA2 SRPRB TAB1 TAX1BP3 TSPYL4 UFL1
Entrez ID		58477	80279
HPRD ID		18105	12190
Ensembl ID		ENSG00000144867	ENSG00000108465
Uniprot IDs		Q549N5 Q9Y5M8	Q96JB5
PDB IDs
Enriched GO Terms of Interacting Partners?
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