PYGB and XRN2

Data Source:
BioGRID (affinity chromatography technology)

		PYGB	XRN2
Description		glycogen phosphorylase B	5'-3' exoribonuclease 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Membrane Azurophil Granule Lumen Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Membrane Aggresome
	Molecular Function	Protein Binding Glycogen Phosphorylase Activity Pyridoxal Phosphate Binding Linear Malto-oligosaccharide Phosphorylase Activity SHG Alpha-glucan Phosphorylase Activity	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Glycogen Catabolic Process Neutrophil Degranulation	DNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Neutrophil degranulation Glycogen breakdown (glycogenolysis)	Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Pyridoxal phosphate Alvocidib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Calcium levels ( 24068962) Diisocyanate-induced asthma ( 25918132) Liver enzyme levels (alkaline phosphatase) ( 22001757) Platelet distribution width ( 32888494) Serum alkaline phosphatase levels ( 31666285) Telomere length ( 30185882) TPE interval (resting) ( 32386560)	Autism spectrum disorder ( 30804558) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		5 interacting genes: ACTN1 PPP1R3B PYGL PYGM SIAH1	28 interacting genes: ALDH1B1 ATRN COMT CRY2 CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MOCS3 MRPL4 MRPS10 PLEKHF2 PRAME PSMA3 TARDBP TIPARP TOLLIP TTC23 UPF2
Entrez ID		5834	22803
HPRD ID		00720	10309
Ensembl ID		ENSG00000100994	ENSG00000088930
Uniprot IDs		P11216	B4DZC3 Q9H0D6
PDB IDs		5IKO 5IKP
Enriched GO Terms of Interacting Partners?
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