BBS1 and BHMT

Data Source:
BioGRID (two hybrid)

		BBS1	BHMT
Description		Bardet-Biedl syndrome 1	betaine--homocysteine S-methyltransferase
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GO Annotations	Cellular Component	Centrosome Cytosol Axoneme BBSome Ciliary Basal Body Ciliary Membrane	Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Patched Binding Smoothened Binding Protein Binding	Zinc Ion Binding Betaine-homocysteine S-methyltransferase Activity
	Biological Process	Visual Perception Sensory Perception Of Smell Golgi To Plasma Membrane Protein Transport Photoreceptor Cell Maintenance Response To Stimulus Cilium Assembly Protein Localization To Cilium Non-motile Cilium Assembly	Sulfur Amino Acid Metabolic Process Protein Methylation Amino-acid Betaine Metabolic Process Amino-acid Betaine Catabolic Process Choline Catabolic Process S-adenosylmethionine Metabolic Process Regulation Of Homocysteine Metabolic Process L-methionine Salvage
Pathways		BBSome-mediated cargo-targeting to cilium	Sulfur amino acid metabolism Choline catabolism
Drugs			Methionine S-(D-Carboxybutyl)-L-Homocysteine
Diseases		Bardet-Biedl syndrome (BBS)
GWAS		Bipolar disorder ( 21926972) Height ( 28552196)	Betaine levels in individuals undergoing cardiac evaluation ( 26822151) Blood and toenail selenium levels ( 25343990) Blood metabolite levels ( 24816252) Blood trace element (Se levels) ( 23720494) Metabolite levels ( 23823483 23378610) Toenail selenium levels ( 25343990)
Interacting Genes		13 interacting genes: BHMT CALCA DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB KRT18 PARK7 PAX2 TSPAN7	6 interacting genes: ALG9 BBS1 BBS2 BBS4 LAMTOR3 LAMTOR5
Entrez ID		582	635
HPRD ID		01950	04200
Ensembl ID		ENSG00000174483	ENSG00000145692
Uniprot IDs		Q8NFJ9	Q93088 V9HWA4
PDB IDs		6XT9	1LT7 1LT8 4M3P
Enriched GO Terms of Interacting Partners?
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