WFDC1 and ETF1

Data Source:
BioGRID (affinity chromatography technology)

		WFDC1	ETF1
Description		WAP four-disulfide core domain 1	eukaryotic translation termination factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Nucleus Cytoplasm Cytosol Translation Release Factor Complex
	Molecular Function	Molecular_function Serine-type Endopeptidase Inhibitor Activity	RNA Binding Translation Release Factor Activity Protein Binding Translation Termination Factor Activity Translation Release Factor Activity, Codon Specific Ribosome Binding Sequence-specific MRNA Binding
	Biological Process	Regulation Of Cell Growth Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell Growth Response To Estradiol Response To Drug Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Negative Regulation Of Wound Healing	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translational Termination Translational Termination Regulation Of Translational Termination Protein Methylation
Pathways			Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Systolic blood pressure (alcohol consumption interaction) ( 24376456) Visceral adipose tissue adjusted for BMI ( 22589738)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) California verbal learning test score ( 31596458) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) General risk tolerance (MTAG) ( 30643258) Schizophrenia ( 28991256 25056061 29483656 30285260)
Interacting Genes		5 interacting genes: EZR FOSL1 RAB40B XRCC2 ZNF677	5 interacting genes: GSPT1 GSPT2 KEAP1 LIG4 PPP2CA
Entrez ID		58189	2107
HPRD ID		05614	02616
Ensembl ID		ENSG00000103175	ENSG00000120705
Uniprot IDs		Q9HC57	B7Z7P8 P62495
PDB IDs			1DT9 2HST 2KTU 2KTV 2LGT 2LLX 2MQ6 2MQ9 3E1Y 3J5Y 3JAG 3JAH 3JAI 4D5N 4D61 5A8L 5LZT 5LZU 5LZV 6D90 6IP8 6XA1 6ZME
Enriched GO Terms of Interacting Partners?
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