ETF1 and GSPT1

Data Source:
BioGRID (proximity labelling technology, affinity chromatography technology)
HPRD (two hybrid, in vivo)

		ETF1	GSPT1
Description		eukaryotic translation termination factor 1	G1 to S phase transition 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Translation Release Factor Complex	Cytosol Translation Release Factor Complex
	Molecular Function	RNA Binding Translation Release Factor Activity Protein Binding Translation Termination Factor Activity Translation Release Factor Activity, Codon Specific Ribosome Binding Sequence-specific MRNA Binding	RNA Binding Translation Release Factor Activity GTPase Activity Protein Binding GTP Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translational Termination Translational Termination Regulation Of Translational Termination Protein Methylation	G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translational Termination Translation Regulation Of Translational Termination Protein Methylation
Pathways		Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) California verbal learning test score ( 31596458) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) General risk tolerance (MTAG) ( 30643258) Schizophrenia ( 28991256 25056061 29483656 30285260)	Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494) Menopause (age at onset) ( 26414677) Red blood cell count ( 32888494) Testicular germ cell tumor ( 26503584)
Interacting Genes		5 interacting genes: GSPT1 GSPT2 KEAP1 LIG4 PPP2CA	12 interacting genes: ATXN1 BIRC2 BIRC3 CDKN2A CRBN DDB1 ETF1 GSPT2 HINFP PABPC1 PIK3R1 XIAP
Entrez ID		2107	2935
HPRD ID		02616	00753
Ensembl ID		ENSG00000120705	ENSG00000103342
Uniprot IDs		B7Z7P8 P62495	B2RCT6 P15170 Q7KZX8
PDB IDs		1DT9 2HST 2KTU 2KTV 2LGT 2LLX 2MQ6 2MQ9 3E1Y 3J5Y 3JAG 3JAH 3JAI 4D5N 4D61 5A8L 5LZT 5LZU 5LZV 6D90 6IP8 6XA1 6ZME	3E1Y 3J5Y 3KUI 4D61 5HXB 5LZT
Enriched GO Terms of Interacting Partners?
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