NGB and HLCS

Data Source:
BioGRID (affinity chromatography technology)

		NGB	HLCS
Description		neuroglobin	holocarboxylase synthetase
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol Perikaryon	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Metal Ion Binding	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding
	Biological Process	Apoptotic Process Oxygen Transport	Biotin Metabolic Process Protein Biotinylation Histone Modification Protein Phosphopantetheinylation Response To Biotin Histone Biotinylation
Pathways		Intracellular oxygen transport	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs			Biotin
Diseases			Holocarboxylase synthetase deficiency
GWAS			Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)
Interacting Genes		21 interacting genes: AKT1 ATP1B2 BTBD2 C1orf94 DDIT4L FLOT1 GATAD2B GNAI1 GNAI2 GNAI3 GNAO1 IHO1 L3MBTL3 MEI4 NIF3L1 PTEN REL TDO2 TEPSIN VAC14 ZNF655	8 interacting genes: ACACB ANKRD29 DDX52 KRTAP5-9 MED19 POT1 SNX27 SPATA46
Entrez ID		58157	3141
HPRD ID		05602	08360
Ensembl ID		ENSG00000165553	ENSG00000159267
Uniprot IDs		A0M8W9 Q9NPG2	P50747
PDB IDs		1OJ6 4MPM
Enriched GO Terms of Interacting Partners?
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