PTPRN2 and CKAP5

Data Source:
HPRD (two hybrid)

		PTPRN2	CKAP5
Description		protein tyrosine phosphatase receptor type N2	cytoskeleton associated protein 5
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GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Synaptic Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Terminal Bouton Receptor Complex Ficolin-1-rich Granule Membrane	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Gamma-tubulin Complex Nucleolus Cytoplasm Centrosome Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Protein-containing Complex Microtubule Plus-end
	Molecular Function	Transmembrane Receptor Protein Tyrosine Phosphatase Activity	Protein Binding Microtubule Binding Ribonucleoprotein Complex Binding Cadherin Binding Microtubule Plus End Polymerase
	Biological Process	Protein Dephosphorylation Lipid Metabolic Process Neurotransmitter Secretion Negative Regulation Of GTPase Activity Peptidyl-tyrosine Dephosphorylation Insulin Secretion Involved In Cellular Response To Glucose Stimulus Neutrophil Degranulation	G2/M Transition Of Mitotic Cell Cycle Microtubule Depolymerization Spindle Organization Mitotic Spindle Organization Centrosome Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Microtubule Polymerization RNA Transport Centrosome Duplication Cell Division Positive Regulation Of Microtubule Nucleation Ciliary Basal Body-plasma Membrane Docking
Pathways		Neutrophil degranulation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Bipolar disorder and schizophrenia ( 21057379) Breast cancer in childhood cancer survivors ( 29059430) Breast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy ( 29059430) Calcium levels ( 25972035) Carotid plaque burden ( 28282560) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Diastolic blood pressure ( 27841878) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) Inflammatory skin disease ( 25574825) Intelligence (MTAG) ( 29326435) Myopia (pathological) ( 23049088) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Obesity-related traits ( 23251661) Plasma anti-thyroid peroxidase levels ( 29678681) Refractive error ( 32231278) Response to amphetamines ( 22952603) Retinal detachment or retinal break ( 31816047) Serum metabolite concentrations in chronic kidney disease ( 29545352) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Triacylglyceride levels ( 31551469)	Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Immunoglobulin A ( 20694011) Pulse pressure ( 30578418) Schizophrenia ( 29483656)
Interacting Genes		3 interacting genes: CKAP5 SPTBN4 UBQLN4	11 interacting genes: ARHGEF16 AURKA CACNA1A CLASP1 CLK1 NDC80 PTPRN2 SLAIN2 SUMO2 TOP1 USP19
Entrez ID		5799	9793
HPRD ID		03413	10830
Ensembl ID		ENSG00000155093	ENSG00000175216
Uniprot IDs		E7EM83 I6L9F8 Q92932	Q14008
PDB IDs		2QEP 4HTI 4HTJ	4QMI 4QMJ
Enriched GO Terms of Interacting Partners?
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