PTPRE and PTPRS

Data Source:
HPRD (in vivo)

		PTPRE	PTPRS
Description		protein tyrosine phosphatase receptor type E	protein tyrosine phosphatase receptor type S
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Membrane	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Synaptic Vesicle Membrane Axon Growth Cone Perikaryon Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Heparin Binding Chondroitin Sulfate Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway	Protein Dephosphorylation Negative Regulation Of Neuron Projection Development Spinal Cord Development Cerebellum Development Hippocampus Development Cerebral Cortex Development Corpus Callosum Development Negative Regulation Of Axon Extension Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Toll-like Receptor 9 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Modulation Of Chemical Synaptic Transmission Negative Regulation Of Dendritic Spine Development Establishment Of Endothelial Intestinal Barrier Regulation Of Postsynaptic Density Assembly Synaptic Membrane Adhesion
Pathways			ECM proteoglycans Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules Signaling by NTRK3 (TRKC)
Drugs		Alendronic acid Tiludronic acid	Alendronic acid Etidronic acid
Diseases
GWAS		Response to amphetamines ( 22952603) Select biomarker traits ( 17903293) Triglyceride levels x loop diuretics use interaction ( 31806883)	Thyroid stimulating hormone levels ( 32769997) Type 2 diabetes ( 30297969) Waist-hip ratio ( 28552196)
Interacting Genes		10 interacting genes: FYN GRB2 KCNA5 KCNB1 MAPK1 MAPK3 PTPRD PTPRS SRC YES1	27 interacting genes: CEP126 CHD3 EEF1G EGFR FEZ1 GPC2 GPC3 GPC6 KAT5 MOB4 PFN2 PPFIA1 PPFIA2 PPFIA3 PTN PTPRA PTPRD PTPRE PTPRM PTPRN RAB35 SETDB1 SLITRK1 TUBB2A UBR1 UNC119 UTP14A
Entrez ID		5791	5802
HPRD ID		02956	03344
Ensembl ID		ENSG00000132334	ENSG00000105426
Uniprot IDs		A8K2Z9 P23469 Q96P81	Q13332 Q59FX6 Q8NHS7
PDB IDs		2JJD 6D3F 6D4D 6D4F	2FH7 2YD2 2YD3 2YD9 4BPC 4PBX
Enriched GO Terms of Interacting Partners?
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