PTPRE and TUBB4B

Data Source:
HPRD (in vivo, in vitro)

		PTPRE	TUBB4B
Description		protein tyrosine phosphatase receptor type E	tubulin beta 4B class IVb
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Azurophil Granule Lumen Extracellular Exosome Extracellular Vesicle
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding	Double-stranded RNA Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding MHC Class I Protein Binding Unfolded Protein Binding
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Natural Killer Cell Mediated Cytotoxicity Neutrophil Degranulation Ciliary Basal Body-plasma Membrane Docking
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs		Alendronic acid Tiludronic acid	Albendazole Mebendazole Epothilone D Patupilone Oxibendazole CYT997 Phenethyl Isothiocyanate
Diseases
GWAS		Response to amphetamines ( 22952603) Select biomarker traits ( 17903293) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		10 interacting genes: FYN GRB2 KCNA5 KCNB1 MAPK1 MAPK3 PTPRD PTPRS SRC YES1	19 interacting genes: ACD CDKN2A DAPK1 DLEU1 DLST ENOX2 LINC01554 NEAT1 POT1 PSME1 PTEN PTPRF SCG2 SOCS6 SOCS7 SUMO2 TERF1 TINF2 TUBG1
Entrez ID		5791	10383
HPRD ID		02956	04043
Ensembl ID		ENSG00000132334	ENSG00000188229
Uniprot IDs		A8K2Z9 P23469 Q96P81	P68371
PDB IDs		2JJD 6D3F 6D4D 6D4F
Enriched GO Terms of Interacting Partners?
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