PTPN14 and CTNNA2

Data Source:
HPRD (in vitro)

		PTPN14	CTNNA2
Description		protein tyrosine phosphatase non-receptor type 14	catenin alpha 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton	Nucleus Cytoplasm Cytosol Plasma Membrane Adherens Junction Actin Cytoskeleton Catenin Complex Axon
	Molecular Function	Transcription Coregulator Activity Protein Tyrosine Phosphatase Activity Protein Binding Receptor Tyrosine Kinase Binding	Structural Constituent Of Cytoskeleton Protein Binding Beta-catenin Binding Cadherin Binding Actin Filament Binding
	Biological Process	Lymphangiogenesis Regulation Of Transcription, DNA-templated Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Peptidyl-tyrosine Dephosphorylation Regulation Of Protein Export From Nucleus Cellular Response To Cytokine Stimulus	Cytoskeleton Organization Axonogenesis Regulation Of Neuron Projection Development Cell Migration Radial Glia Guided Migration Of Purkinje Cell Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendrite Morphogenesis Brain Morphogenesis Positive Regulation Of Muscle Cell Differentiation Regulation Of Synapse Structural Plasticity Prepulse Inhibition Cell-cell Adhesion Regulation Of Neuron Migration
Pathways		Interleukin-37 signaling	Myogenesis Myogenesis
Drugs
Diseases		Choanal atresia and lymphedema
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Birth weight ( 31043758) Bone mineral density (hip) ( 30172743) Estimated glomerular filtration rate ( 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Height ( 28552196 25429064 31562340) Lipid traits ( 24386095) Plasma thyroid-stimulating hormone levels ( 24722205)	Adult body size ( 32376654) Alcohol consumption ( 28937693) Alcohol dependence or heroin dependence or methamphetamine dependence ( 31462767) Alzheimer's disease (cognitive decline) ( 23535033) Bipolar disorder ( 19416921) Body mass index ( 26426971 25673413) Bone mineral density (femoral neck) ( 26911590) Breast cancer ( 25824743) Cerebral microbleeds ( 31209788) Cerebrospinal fluid clusterin levels ( 26545630) Cleft palate ( 30452639) Cognitive function ( 25644384) Contrast sensitivity ( 24152035) Cooked vegetable consumption ( 32066663) Fish- and plant-related diet ( 32066663) Gut microbiota relative abundance (Bacteroides) ( 33208821) Mild influenza (H1N1) infection ( 26379185) Multisite chronic pain ( 31194737) Orthostatic hypotension ( 24124408) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Protein quantitative trait loci ( 18464913) Raw vegetable consumption ( 32066663) Refractive error ( 32231278) Response to cytadine analogues (cytosine arabinoside) ( 24483146) Response to lurasidone in schizophrenia ( 29730043) Schizophrenia (MTAG) ( 32107650) Survival in pancreatic cancer ( 28470677)
Interacting Genes		8 interacting genes: AMOT CDH1 CTNNA2 CTNNB1 JUP TJP1 TRIP6 YWHAG	2 interacting genes: CTNNBIP1 PTPN14
Entrez ID		5784	1496
HPRD ID		04402	00228
Ensembl ID		ENSG00000152104	ENSG00000066032
Uniprot IDs		A8K6H6 Q15678	F6KRI5 P26232 Q49AD3
PDB IDs		2BZL 6IWD 6JJW	6DUW
Enriched GO Terms of Interacting Partners?
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