SLAMF7 and SVIL

Data Source:
BioGRID (affinity chromatography technology)

		SLAMF7	SVIL
Description		SLAM family member 7	supervillin
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Midbody Cleavage Furrow Microtubule Minus-end Costamere
	Molecular Function	Identical Protein Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding
	Biological Process	Adaptive Immune Response Cell Adhesion Natural Killer Cell Activation Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response	Skeletal Muscle Tissue Development Actin Polymerization Or Depolymerization Positive Regulation Of Cytokinesis Actin Filament Severing Barbed-end Actin Filament Capping
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Elotuzumab
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) IgM levels ( 28628107) Inflammatory bowel disease ( 23128233) Microalbuminuria ( 26631737) Multiple sclerosis ( 24076602)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Bone fracture in osteoporosis ( 28580392) Estimated glomerular filtration rate ( 31152163) Lung function (FEV1/FVC) ( 28166213) Metabolite levels ( 23823483) Neurofibrillary tangles ( 25188341) Normalized brain volume ( 19010793) Platelet thrombus formation ( 22550155) Plateletcrit ( 32888494)
Interacting Genes		4 interacting genes: CLK3 MAK SH2D1A TRIB2	35 interacting genes: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF22 KIFC3 KMT2A KRT18 LMNA LMNB2 LUC7L2 MIF4GD MPHOSPH9 MRTFB NME2 NR3C1 ODF2 P2RX7 PAN3 PCNX3 PPARG SH3PXD2A STARD9 TGFB1I1 TNFAIP1 TRIP6 UXT YWHAG
Entrez ID		57823	6840
HPRD ID		09432	04992
Ensembl ID		ENSG00000026751	ENSG00000197321
Uniprot IDs		B4DVL7 B4DW98 Q9NQ25	A0A6I8PIX7 O95425 Q569J5
PDB IDs			2K6M 2K6N
Enriched GO Terms of Interacting Partners?
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