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PTPN6 and CXCR4
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
PTPN6
CXCR4
Description
protein tyrosine phosphatase non-receptor type 6
C-X-C motif chemokine receptor 4
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cell-cell Junction
Membrane
Protein-containing Complex
Specific Granule Lumen
Alpha-beta T Cell Receptor Complex
Extracellular Exosome
Tertiary Granule Lumen
Nucleus
Cytoplasm
Lysosome
Early Endosome
Late Endosome
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Integral Component Of Membrane
Cell Junction
Cell Leading Edge
Cytoplasmic Vesicle
Protein-containing Complex
Extracellular Exosome
Molecular Function
Phosphotyrosine Residue Binding
Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
SH2 Domain Binding
Cell Adhesion Molecule Binding
Phosphorylation-dependent Protein Binding
Virus Receptor Activity
Actin Binding
G Protein-coupled Receptor Activity
Protein Binding
Coreceptor Activity
C-C Chemokine Receptor Activity
C-X-C Chemokine Receptor Activity
C-C Chemokine Binding
Ubiquitin Protein Ligase Binding
Myosin Light Chain Binding
C-X-C Motif Chemokine 12 Receptor Activity
Identical Protein Binding
Ubiquitin Binding
Biological Process
Hematopoietic Progenitor Cell Differentiation
Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Protein Dephosphorylation
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Platelet Activation
Platelet Formation
T Cell Costimulation
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Abortive Mitotic Cell Cycle
Positive Regulation Of Cell Adhesion Mediated By Integrin
Peptidyl-tyrosine Dephosphorylation
Intracellular Signal Transduction
Megakaryocyte Development
Negative Regulation Of T Cell Proliferation
Natural Killer Cell Mediated Cytotoxicity
Regulation Of Apoptotic Process
Neutrophil Degranulation
Negative Regulation Of MAP Kinase Activity
Regulation Of B Cell Differentiation
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
B Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Leukocyte Migration
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Cellular Response To Cytokine Stimulus
Epididymis Development
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Activation Of MAPK Activity
Response To Hypoxia
Neuron Migration
Epithelial Cell Development
Dendritic Cell Chemotaxis
Apoptotic Process
Inflammatory Response
Immune Response
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Axon Guidance
Brain Development
Neuron Recognition
Response To Virus
Response To Activity
Fusion Of Virus Membrane With Host Plasma Membrane
Calcium-mediated Signaling
Neurogenesis
Telencephalon Cell Migration
Regulation Of Cell Adhesion
Positive Regulation Of Vascular Wound Healing
Cellular Response To Drug
CXCL12-activated CXCR4 Signaling Pathway
Regulation Of Programmed Cell Death
Myelin Maintenance
Response To Morphine
Endothelial Cell Differentiation
Positive Regulation Of Oligodendrocyte Differentiation
Regulation Of Viral Process
Regulation Of Chemotaxis
Positive Regulation Of Chemotaxis
Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Regulation Of Calcium Ion Transport
Cardiac Muscle Contraction
Cell Chemotaxis
Endothelial Tube Morphogenesis
Cellular Response To Cytokine Stimulus
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Dendrite Extension
Positive Regulation Of Mesenchymal Stem Cell Migration
Response To Ultrasound
Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways
GPVI-mediated activation cascade
Regulation of KIT signaling
PECAM1 interactions
Costimulation by the CD28 family
PD-1 signaling
Signal regulatory protein family interactions
Platelet sensitization by LDL
Interleukin-3, Interleukin-5 and GM-CSF signaling
CD22 mediated BCR regulation
Neutrophil degranulation
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin-37 signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA signaling
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Binding and entry of HIV virion
Signaling by ROBO receptors
Chemokine receptors bind chemokines
G alpha (i) signalling events
Drugs
Tiludronic acid
Framycetin
AMD-070
Plerixafor
Ibalizumab
Diseases
Chemokine receptor defect, including the following disease: WHIM syndrome
GWAS
Mean corpuscular hemoglobin concentration (
29403010
)
Red blood cell fatty acid levels (
25500335
)
Refractive error (
32231278
)
Albumin-globulin ratio (
29403010
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Arthritis (juvenile idiopathic) (
27005825
)
Attention deficit hyperactivity disorder (
32595297
)
Body mass index (
26426971
)
Colorectal cancer (
29228715
)
Estimated glomerular filtration rate (
31152163
)
Lung function (low FEV1 vs high FEV1) (
26423011
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Multiple sclerosis (
31604244
19525953
)
Non-albumin protein levels (
29403010
)
Smoking status (ever vs never smokers) (
30643258
)
Telomere length (
20421499
)
White blood cell count (
32888494
)
Interacting Genes
114 interacting genes:
AATK
ABL1
ACTN1
ACTN4
BCR
BLNK
BTLA
CAV1
CBL
CCDC88A
CD22
CD247
CD300LF
CD33
CD5
CD72
CD79A
CD79B
CDK1
CEACAM1
CLEC4A
CSF2RB
CTNNB1
CTNND1
CUZD1
CXCR4
DOK1
EGFR
EPOR
ERBB2
ERBB3
ERBB4
ESR1
FAS
FCGR2B
FCRL3
FGFR4
FHL3
FLT3
GAB2
GHR
GRB2
HOXA10
IFNAR1
IGF1R
IL2RB
IL4R
IL6ST
INSR
IRS2
IRS4
JAK1
JAK2
JAK3
KDR
KHDRBS1
KIR2DL3
KIR2DL5A
KIT
KLRA1P
KLRB1
KLRC1
LAIR1
LAT
LCK
LCP2
LIFR
LILRB2
LILRB4
LMTK2
LYN
MPIG6B
MS4A2
MYH9
NOS1
OLIG1
PAG1
PDGFRB
PECAM1
PIK3R1
PILRA
PILRB
PLCG2
PRKCA
PRKCD
PTK2B
PTK7
PTPN11
PTPRC
ROR1
ROR2
ROS1
SHC1
SIGLEC10
SIGLEC11
SIGLEC12
SIRPA
SLAMF6
SOS1
SPATA2
SRC
SSTR2
STAT5B
STAT6
SYK
TFG
TLR10
TMEM62
TNFRSF1A
TRAF6
TREML1
TYK2
VAV1
ZAP70
34 interacting genes:
ARRB2
ATP13A2
B2M
CCR5
CD4
CTSG
CXCL12
DPP4
DUXAP9
ELANE
GNA13
GNAI1
GRK3
HSPA8
ITCH
JAK1
JAK2
JAK3
MYBL2
MYH9
PTK2
PTPN11
PTPN6
PTPRC
RNF113A
SDC4
SOCS1
SOCS3
STAT1
STAT2
STAT3
STAT5B
USP14
VAV1
Entrez ID
5777
7852
HPRD ID
01475
01217
Ensembl ID
ENSG00000111679
ENSG00000121966
Uniprot IDs
P29350
Q53XS4
A0A0U3FJG0
A0A0U3GXA9
P61073
PDB IDs
1FPR
1GWZ
1X6C
2B3O
2RMX
2YU7
3PS5
4GRY
4GRZ
4GS0
4HJP
4HJQ
2K03
2K04
2K05
2N55
3ODU
3OE0
3OE6
3OE8
3OE9
4RWS
Enriched GO Terms of Interacting Partners
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