GBA3 and PRKCSH

Data Source:
BioGRID (two hybrid)

		GBA3	PRKCSH
Description		glucosylceramidase beta 3 (gene/pseudogene)	protein kinase C substrate 80K-H
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Catalytic Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Glucosidase II Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Galactosylceramidase Activity Glucosylceramidase Activity Beta-galactosidase Activity Protein Binding Beta-glucosidase Activity Glycosylceramidase Activity Scopolin Beta-glucosidase Activity	Protein Kinase C Binding Calcium Ion Binding Protein Binding Ion Channel Binding Phosphoprotein Binding
	Biological Process	Glucosylceramide Catabolic Process Galactosylceramide Catabolic Process Glycosphingolipid Metabolic Process Glycoside Catabolic Process Glycosylceramide Catabolic Process Protein Stabilization Cellular Oligosaccharide Catabolic Process Beta-glucoside Catabolic Process Positive Regulation Of Exo-alpha-sialidase Activity	Liver Development Protein Folding N-glycan Processing Intracellular Signal Transduction Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Glycosphingolipid metabolism	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) N-glycan trimming in the ER and Calnexin/Calreticulin cycle Advanced glycosylation endproduct receptor signaling Post-translational protein phosphorylation Calnexin/calreticulin cycle Maturation of spike protein Maturation of spike protein
Drugs
Diseases			Polycystic liver disease
GWAS		Ankylosing spondylitis ( 30946743) Anti-saccade response ( 29064472) Blood metabolite levels ( 24816252) Manganese levels ( 26025379) Metabolite levels ( 23823483) Peak cortisol response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Rosacea symptom severity ( 29771307) Serum metabolite levels ( 23093944) Tourette's syndrome or obsessive-compulsive disorder ( 25158072) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)	Presence of antiphospholipid antibodies ( 27098658) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		2 interacting genes: PRKCSH TNS2	10 interacting genes: ARL4D CANX ESR1 GANAB GBA3 GET4 PTPRC RGS2 RPS6 VDR
Entrez ID		57733	5589
HPRD ID		09428	03518
Ensembl ID		ENSG00000249948	ENSG00000130175
Uniprot IDs		A8K9N1 B7Z536 Q9H227	B4DJQ5 K7ELL7 P14314
PDB IDs		2E9L 2E9M 2JFE 2ZOX 3VKK
Enriched GO Terms of Interacting Partners?
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