LRRC4C and DOLK

Data Source:
BioGRID (two hybrid)

		LRRC4C	DOLK
Description		leucine rich repeat containing 4C	dolichol kinase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Membrane Integral Component Of Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Cell Adhesion Molecule Binding Cell-cell Adhesion Mediator Activity	Dolichol Kinase Activity Protein Binding
	Biological Process	Regulation Of Axonogenesis Modulation Of Chemical Synaptic Transmission Synaptic Membrane Adhesion	Dolichyl Diphosphate Biosynthetic Process Phosphorylation Dolichyl Monophosphate Biosynthetic Process
Pathways			Synthesis of Dolichyl-phosphate Defective DOLK causes DOLK-CDG (CDG-1m)
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Blood protein levels ( 30072576) Cerebellum cortex volume ( 31530798) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Cerebrospinal fluid p-tau levels ( 29274321) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) General risk tolerance (MTAG) ( 30643258) High myopia ( 31816047) Iris color (L* coordinate) ( 30895295) Mosquito bite size ( 28199695) Myopia ( 27182965) Osteoporosis-related phenotypes ( 20548944) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Survival in colorectal cancer ( 26586795) Temperament (bipolar disorder) ( 22365631)
Interacting Genes		28 interacting genes: AGTRAP BDKRB1 BMP10 BRICD5 CLDN19 CLEC1A CLEC4G CMTM5 CREB3L4 DOLK DRAM1 EMP3 GJB2 LEPROTL1 LHFPL5 MIP NTNG1 PGAP2 PLP2 SERTM1 SMIM1 SNAP47 STX5 TWSG1 VEZT VSTM1 WHRN YIPF6	22 interacting genes: APPBP2 CD79A CHODL CREB3 CREB3L1 EDA FAM209A FNDC9 GALNT8 GJA8 GPX8 KCNA1 KCNA10 KCNA3 KCNA6 LRRC4C SLC7A6 SYNPR TMEM45B TMEM80 UBQLN1 VSIR
Entrez ID		57689	22845
HPRD ID		12303	15525
Ensembl ID		ENSG00000148948	ENSG00000175283
Uniprot IDs		Q4JIV9 Q4JIW0 Q9HCJ2	A0A0S2Z597 Q9UPQ8
PDB IDs		3ZYJ
Enriched GO Terms of Interacting Partners?
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