ZBTB2 and TMC6

Data Source:
BioGRID (two hybrid)

		ZBTB2	TMC6
Description		zinc finger and BTB domain containing 2	transmembrane channel like 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Nuclear Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Mechanosensitive Ion Channel Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Biological_process Ion Transmembrane Transport Neutrophil Degranulation
Pathways			Neutrophil degranulation
Drugs
Diseases			Epidermodysplasia verruciformis
GWAS		Chronic myeloid leukemia ( 21540461) Refractive error ( 32231278)	Glycated hemoglobin levels ( 31213470 28887542 29170429) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin A1c levels ( 29403010) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Red blood cell count ( 29403010 32888494 27863252) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Serum uric acid levels ( 29559957)
Interacting Genes		28 interacting genes: CREBBP DAXX GABARAPL2 IP6K2 KAT5 LHX4 LNX1 MEOX2 MKLN1 MOS MRPL11 PICK1 PIN1 RASSF8 SP1 STAT6 SUMO1 SUMO2 SUV39H1 TENT5B TMC6 TP53 UBE2I ZBTB18 ZBTB25 ZBTB49 ZMYND19 ZNF639	3 interacting genes: CCR9 ZBTB2 ZDHHC17
Entrez ID		57621	11322
HPRD ID		10314	08386
Ensembl ID		ENSG00000181472	ENSG00000141524
Uniprot IDs		Q8N680	A0A024R8V2 Q7Z403
PDB IDs
Enriched GO Terms of Interacting Partners?
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