PTMA and PTPN2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PTMA	PTPN2
Description		prothymosin alpha	protein tyrosine phosphatase non-receptor type 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane
	Molecular Function	Protein Binding Activating Transcription Factor Binding	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding Protein Kinase Binding Syntaxin Binding Receptor Tyrosine Kinase Binding STAT Family Protein Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Lipid Storage B Cell Differentiation T Cell Differentiation Erythrocyte Differentiation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Glucose Homeostasis Negative Regulation Of Macrophage Differentiation Positive Regulation Of Gluconeogenesis Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Chemotaxis Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-2-mediated Signaling Pathway Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Negative Regulation Of Positive Thymic T Cell Selection Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways			Negative regulation of MET activity Interleukin-37 signaling
Drugs
Diseases			Type I diabetes mellitus
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494 27863252)	Alopecia areata ( 25608926) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Body mass index ( 25673413) C-reactive protein levels ( 30388399 21300955) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 25489960 28067908 17554261 17554300 21102463) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Esophageal cancer (squamous cell) ( 22960999) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lead levels in blood ( 25820613) Lymphocyte counts ( 32888494) Mean reticulocyte volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Psoriasis ( 28537254) Red blood cell count ( 32888494) Rheumatoid arthritis ( 30423114 22446963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Selective IgA deficiency ( 27723758) Type 1 diabetes ( 21829393 25751624 19430480 17554260 18978792)
Interacting Genes		41 interacting genes: CASP3 CASP7 CCNA2 CCNB1 CDK1 CDK2 CDK4 CREBBP EP300 ESR1 H1-1 H2AC14 H2BC21 H2BC8 H3-4 H3C14 H4C1 H4C14 HDAC1 HDAC2 HSPA1A IL7R KEAP1 KPNA2 KPNB1 NCOR1 NUP62 NUPR1 NUTF2 PCNA PHB2 RAN RCC1 SET SIN3A STAT3 TERF1 TERF2 TERF2IP VIPR1 ZDHHC17	23 interacting genes: CDK1 CDK2 CDK5 EGFR FAM220A FKBP4 GHR GJB1 INSR ITGA1 JAK1 JAK3 KPNB1 OCLN PDGFRB SHC1 SRC STAT1 STAT3 STAT5A STAT5B STX17 UBC
Entrez ID		5757	5771
HPRD ID		01778	06768
Ensembl ID		ENSG00000187514	ENSG00000175354
Uniprot IDs		P06454 Q53S24	A8K3N4 D3DUJ3 K7EQG9 P17706 Q59F91
PDB IDs		2L9I 2MNQ	1L8K
Enriched GO Terms of Interacting Partners?
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