PTMA and H1-1

Data Source:
HPRD (in vitro)

		PTMA	H1-1
Description		prothymosin alpha	H1.1 linker histone, cluster member
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding Activating Transcription Factor Binding	Double-stranded DNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Apoptotic Process	Nucleosome Assembly Spermatogenesis Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination
Pathways			Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494 27863252)
Interacting Genes		41 interacting genes: CASP3 CASP7 CCNA2 CCNB1 CDK1 CDK2 CDK4 CREBBP EP300 ESR1 H1-1 H2AC14 H2BC21 H2BC8 H3-4 H3C14 H4C1 H4C14 HDAC1 HDAC2 HSPA1A IL7R KEAP1 KPNA2 KPNB1 NCOR1 NUP62 NUPR1 NUTF2 PCNA PHB2 RAN RCC1 SET SIN3A STAT3 TERF1 TERF2 TERF2IP VIPR1 ZDHHC17	52 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L1 NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SET SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1
Entrez ID		5757	3024
HPRD ID		01778	00820
Ensembl ID		ENSG00000187514	ENSG00000124610
Uniprot IDs		P06454 Q53S24	Q02539
PDB IDs		2L9I 2MNQ
Enriched GO Terms of Interacting Partners?
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