KLHL42 and POMC

Data Source:
BioGRID (two hybrid)

		KLHL42	POMC
Description		kelch like family member 42	proopiomelanocortin
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Cytosol Cul3-RING Ubiquitin Ligase Complex	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Secretory Granule Lumen
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Protein Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding
	Biological Process	Protein Polyubiquitination Cell Cycle Regulation Of Microtubule-based Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cell Division	Generation Of Precursor Metabolites And Energy Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Cytokine-mediated Signaling Pathway Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Glycogen Metabolic Process Regulation Of Corticosterone Secretion
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Interleukin-4 and Interleukin-13 signaling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes ADORA2B mediated anti-inflammatory cytokines production
Drugs			Loperamide Etorphine Dihydromorphine
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gut microbiota (functional units) ( 27694959) Height ( 31562340) Osteoarthritis (hip) ( 30664745) Refractive error ( 32231278) Resting heart rate ( 27798624) Type 2 diabetes ( 30054458)	Body mass index ( 26426971 23669352 20935630) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 28552196 23563607 18391951) Inflammatory bowel disease ( 28067908) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Red vs. brown/black hair color ( 30531825) Type 1 diabetes ( 21980299)
Interacting Genes		35 interacting genes: ADD1 ANKRD33 CALCOCO2 CDCA4 CKMT2 COIL CT55 CUL3 DAZAP2 DDI1 FAM168A INCA1 KRTAP19-4 MYOG OIP5 OSTF1 P4HB PFDN5 POMC RCN3 REL SERTAD1 SERTAD3 SSX2IP STAM2 STXBP4 TRIM23 TRIM54 TTC23 UBE2E3 UBQLN1 UBQLN2 UBQLN4 USHBP1 VPS52	28 interacting genes: ABI2 APP ATP6V0D2 BHLHA9 C1orf109 CCDC102B ESRRG FGF10 GLYCTK HDDC2 HLA-DRB3 HSF2BP KLHL42 MC1R MC2R MC3R MC4R MC5R MEP1A MKRN3 NFKBID NRDC NTAQ1 OAZ3 PAM SUOX TXN2 VTN
Entrez ID		57542	5443
HPRD ID		17237	01462
Ensembl ID		ENSG00000087448	ENSG00000115138
Uniprot IDs		B2RNT7 F5H523 Q9P2K6	P01189
PDB IDs			4XNH 4XPD 4Y49 6TUB
Enriched GO Terms of Interacting Partners?
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