NLN and CWC27

Data Source:
BioGRID (affinity chromatography technology)

		NLN	CWC27
Description		neurolysin	CWC27 spliceosome associated cyclophilin
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GO Annotations	Cellular Component	Extracellular Region Mitochondrial Intermembrane Space Plasma Membrane	Nucleoplasm U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Metalloendopeptidase Activity Peptide Binding Metal Ion Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Cyclosporin A Binding
	Biological Process	Regulation Of Gluconeogenesis Proteolysis Peptide Metabolic Process Regulation Of Skeletal Muscle Fiber Differentiation	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization Protein Folding
Pathways		Peptide ligand-binding receptors	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid AB1-42 levels ( 28247064) Cortical surface area (MOSTest) ( 32665545) Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Refractive astigmatism ( 25367360) Subcortical volume (MOSTest) ( 32665545)	Adult body size ( 32376654) Bladder cancer ( 27206850) Central corneal thickness ( 31798171 29760442) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Obesity-related traits ( 23251661) Refractive error ( 32231278) Systolic blood pressure ( 30224653) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		2 interacting genes: APP NTS	4 interacting genes: CLK1 FRA10AC1 HMGA1 MORF4L1
Entrez ID		57486	10283
HPRD ID		07495	11541
Ensembl ID		ENSG00000123213	ENSG00000153015
Uniprot IDs		Q9BYT8	D6REK3 Q6UX04
PDB IDs		5LUZ 5LV0	2HQ6 4R3E 5Z56 5Z58 6FF4 6FF7 6YVH
Enriched GO Terms of Interacting Partners?
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