PTGIS and GMFG

Data Source:
BioGRID (biochemical)

		PTGIS	GMFG
Description		prostaglandin I2 synthase	glia maturation factor gamma
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Caveola Integral Component Of Membrane	Extracellular Region Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Prostaglandin-I Synthase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Hydroperoxy Icosatetraenoate Dehydratase Activity	Actin Binding Protein Kinase Inhibitor Activity Enzyme Activator Activity Growth Factor Activity Arp2/3 Complex Binding
	Biological Process	Prostaglandin Biosynthetic Process Icosanoid Metabolic Process Cyclooxygenase Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Hypoxia Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis	Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Signal Transduction Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Neutrophil Degranulation Actin Filament Debranching Regulation Of Actin Cytoskeleton Reorganization
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Nicotinamide salvaging Eicosanoids Sterols are 12-hydroxylated by CYP8B1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Neutrophil degranulation
Drugs		Phenylbutazone Epoprostenol (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-1-Octen-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}-5-heptenoic acid
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Schizophrenia ( 25056061 29483656 30285260)	Lung adenocarcinoma ( 28604730)
Interacting Genes		3 interacting genes: APP PTGS1 PTGS2	3 interacting genes: CAMK1D PSD VANGL1
Entrez ID		5740	9535
HPRD ID		09046	06821
Ensembl ID		ENSG00000124212	ENSG00000130755
Uniprot IDs		Q16647	M0R1D2 O60234
PDB IDs		2IAG 3B6H	3L50
Enriched GO Terms of Interacting Partners?
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